Cayman Chemical SulfIsoxazole 25g
A potent and selective inhibitor of Aurora A kinase (IC50s 3.4 and 3400 nM for Aurora A and Aurora B respectively) prevents centrosome separation and reduces phosphorylated Aurora A but not phosphorylated histone H3 levels at the centrosomes reduces the proliferation of HCT116 and HT-29 colorectal carcinoma cells in vitro (IC50s 0.19 and 2.9 M respectively)