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2′-O-Methyluridine is a modified nucleoside found in T. thermophile tRNA. Its serum level is decreased in breast cancer patients. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which reduces ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
Modified nucleoside
Found in T. thermophile tRNA
Decreased in serum levels in breast cancer patients
Used in siRNA targeting apolipoprotein B
Reduces ApoB protein levels
Prevents IFN-α production
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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity. REPROGRAMMING· Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).· Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.). DIFFERENTIATION· Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).CANCER RESEARCH· Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia
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Pseudothymidine is a C-nucleoside analog of thymidine supplied as a powdered research reagent. It serves as an alternative nucleoside substrate for molecular biology and nucleic acid studies and includes analytical data and recommended storage conditions for laboratory use.
C-nucleoside analog of thymidine.
Molecular formula C10H14N2O5 and molecular weight 242.23.
High purity: 99.4%.
Available in small milligram package sizes (1 mg, 5 mg, 10 mg).
Powder form with storage guidance: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (up to 6 months) or -20°C (up to 1 month).
For research use only; not for clinical or patient use.
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MW 285.2 g/mol, Purity >98%. Purine nucleoside that upon sequential phosphoylation forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesise DNA.