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A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
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MW 375.3 Da, Purity >95%. Stable β-glucosidase probe (470nm). Releases the red fluorescent dye resorufin M0202 upon β-glucosidase enzyme cleavage. Successful in numerous applications in cell biology, high-throughput and high-content screening and diagnostics.