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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity. REPROGRAMMING· Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).· Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.). DIFFERENTIATION· Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).CANCER RESEARCH· Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia
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3-Methyluridine (m3U) is a methylated nucleotide found in ribosomal RNA (rRNA), primarily targeting specific base sites like 23S rRNA. It introduces a methyl group at the N3 position of uracil, influencing RNA's secondary structure stability and base pairing. This regulation impacts ribosome function, including ribosomal subunit binding and tRNA interaction.
Utilized as a key raw material for synthesizing modified nucleotides.
Constructs RNA oligonucleotides with methylation modifications.
Used in studying the effects of RNA methylation on gene expression and drug resistance.
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2'-C-methyluridine is a uridine nucleoside analog supplied as a white to off-white solid for laboratory research. It is used in biochemical and pharmacological studies of nucleoside analogs and as a reagent in enzymatic and antiviral assays.
Provides a uridine analog for nucleoside research.
High purity suitable for analytical and biochemical applications.
Soluble in water; may require ultrasonic agitation for complete dissolution.
Stable when stored as a powder under low-temperature conditions.
Available in small laboratory sizes for research workflows.
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Nucleoside-Analog-2 is a 4'-Azidocytidine analogue that targets and inhibits the replication of the Hepatitis C virus (HCV). It functions as a click chemistry reagent containing an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This product is for research use only.
4'-Azidocytidine analogue
Inhibits hepatitis C virus (HCV) replication
Click chemistry reagent with an azide group
Facilitates CuAAc reactions with alkyne groups
Undergoes SPAAC reactions with DBCO or BCN groups
For research use only
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