Nucleosides
5-Methylcytidine, 98%, Thermo Scientific™
BD Bromodeoxyuridine (BrdU)
A thymidine analog used in cell proliferation studies
Fialuridine, Thermo Scientific™
Sigma Aldrich Fine Chemicals Biosciences Resorufin β-D-glucopyranosidePurity: 90% | 375.33 | 101490-85-1 | MFCD00037662 | 50mg
Resorufin β-D-glucopyranosidePurity: 90% | 375.33 | 101490-85-1 | MFCD00037662 | 50mg
Medchemexpress LLC Pseudouridine | 1445-07-4 | 99.92% | 244.20 | 50 MG
Pseudouridine | 1445-07-4 | 99.92% | 244.20 | 50 MG
Medchemexpress LLC 2'-O-Methyluridine | 2140-76-3 | 99.8% | 258.23 | 5 G
2'-O-Methyluridine is a modified nucleoside that can be found in *T. thermophile* tRNA. Its level in serum is decreased in patients with breast cancer. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which decreases ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
- Found in *T. thermophile* tRNA
- Decreased serum levels in breast cancer patients
- Can be incorporated into siRNA
- Decreases ApoB protein levels in HepG2
- Prevents IFN-α production in isolated human PBMCs
Medchemexpress LLC Trifluridine/tipiracil hydrochloride mixture | 733030-01-8 | 100.0% | 435.76 | 50 MG
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. It is composed of a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). The antitumor activity primarily stems from its inhibition of thymidylate synthase (TS) and its incorporation into DNA.
- Potent and orally active nucleoside antitumor agent
- Composed of a 1:0.5 molar mixture of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI)
- Inhibits thymidylate synthase (TS)
- Incorporates into DNA for antitumor activity
Cayman Chemical 6-thIo-2-DeoxygunosIn 1mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Cayman Chemical XnthosIn 5-monphosphate 100mg
An intermediate in purine metabolism, the product of the rate limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis.