Nucleotides
AURORA BIOLABS LLC Kras G13D, GDP Loaded, 100 μg
Kras is a member of the small G protein RAS family, which are a class of GTPases involved in cell signaling transduction. Kras G13D is present in 1.24% of AACR GENIE cases, with colon adenocarcinoma, colorectal adenocarcinoma, rectal adenocarcinoma, lung adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence.
Medchemexpress LLC Cytidine-5'-triphosphate-15N3 dilithium | 65-47-4 | 97.0% | 498.00 | 1 MG
Cytidine-5'-triphosphate-15N3 dilithium (5'-CTP-15N3) is 15N labeled Cytidine-5'-triphosphate. It is a nucleoside triphosphate that serves as a building block for nucleotides and nucleic acids, and lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). This compound is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in *T. gondii*.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Fitc-labeled ODN 1018 sodium | 5 MG
FITC-labeled ODN 1018 sodium is a synthetic oligonucleotide, presented as a white to light yellow solid. This product is provided as the sodium salt, with a molecular weight of 8171.00, and is designed for research applications.
- Appearance: White to light yellow solid
- Purity: Up to 98.71%
- Molecular weight: 8171.00
- Storage: -20°C in sealed storage, away from moisture
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
Apexbio Technology LLC 5-hme-CTP 50ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Cayman Chemical NIcotInamIde rIbosIdechlorI 5g
A riboside form of nicotinamide; a precursor of NAD+ and a source of vitamin B3; increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM; decreases acetylation of FOXO1 and SOD2 but not tubulin; increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet when used at a dose of 400 mg/kg per day; increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease
Apexbio Technology LLC Aminoallyl-UTP 1ml (10mM)
Aminoallyl-UTP is used for Nucleic Acid Sequence-Based Amplification (NASBA) gene chip-based hybridization detection Eberwine mRNA amplification and RNA labeling During NASBA reactions and Eberwine mRNA amplification processes Aminoallyl-UTP is incorporated into RNA sequences The resulting amino-functionalized RNA molecules can then be conjugated with fluorescent groups via primary amine/NHS ester chemistry (using NHS ester of fluorescent dyes) for subsequent gene chip-based hybridization detection
![Biolegend Cell-Vive™ GMP Ultra-LEAF™ Purified anti-human CD56 (NCAM) SF [5.1H11]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 ug](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502527704.png-250.jpg)
Biolegend Cell-Vive™ GMP Ultra-LEAF™ Purified anti-human CD56 (NCAM) SF [5.1H11]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 ug
Cell-Vive™ GMP Ultra-LEAF™ Purified anti-human CD56 (NCAM) SF [5.1H11]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: FC; Size: 100 ug
Apexbio Technology LLC Ara-CTP 100ul (100 mM)
Ara-CTP is a sugar-modified nucleoside analogue composed of cytosine attached to arabinose phosphorylated as a triphosphate Ara-CTP exerts its biological activity primarily by incorporating into nucleic acid strands during nucleic acid synthesis thereby interfering with DNA polymerase and RNA polymerase activities Upon integration Ara-CTP disrupts nucleic acid elongation and replication steps resulting in strand termination or abnormal formation Based on these pharmacological properties Ara-CTP holds research potential in antiviral studies investigating viral replication mechanisms evaluating polymerase specificity identifying viral enzyme inhibitors and serving as a probe in biochemical assays exploring nucleotide-binding interactions and nucleic acid synthesis fidelity
Cayman Chemical BODIPY 630650X succInImID1mg
An amine-reactive fluorescent probe; has been used, linked to adenosine A1 receptor ligands, as a fluorescent probe to quantify ligand-receptor binding; ex/em = 630/650 nm, respectively
Enzo Life Sciences Bio-16-dUTP (50nmol)
Bio-16-dUTP (Biotin-16-2’-deoxyuridine-5’-triphosphate) can replace TTP in reactions in which it serves as a substrate for E. coli DNA polymerase (holoenzyme and Klenow fragment), T4 and Taq DNA polymerases, reverse transcriptase (from AMV and M-MuLV) and terminal transferase. Bio-16-dUTP can be used to produce biotinylated DNA probes in a variety of labeling reactions including nick translation, random prime labeling, cDNA labeling and 3’-end labeling. The resulting biotin-labeled probe can be used in a variety of hybridization applications incuding Southern blots, Northern blots, or dot blots. The probes can also be used for in situ hybridization procedures on fixed cells and tissues. Alternative name: Biotin-16-2'-deoxyuridine-5'-triphosphate. Concentration: 1mM. Quantity: Sufficient for approximately 50 reactions, following the recommended protocol of ENZ-GEN111. Purity: ≥93% (HPLC). Formulation: Liquid. Solution in water.
Medchemexpress LLC N-acetyladenosine | 16265-37-5 | MFCD30575188 | 99.9% | 309.28 g·mol⁻¹ | C12H15N5O5 | 1 ML
N-acetyladenosine is an adenosine analog supplied as a ready-to-use 10 mM solution in DMSO (1 mL) for research use. It exhibits vasodilatory activity and has reported effects on cancer progression pathways. The product is provided with high reported purity and recommended storage conditions for both powder and solution forms.
- Ready-to-use 10 mM solution in DMSO.
- Supplied in a 1 mL vial.
- Reported purity 99.86%.
- CAS number 16265-37-5 for unambiguous identification.
- Chemical formula C12H15N5O5 and molecular weight 309.28 g·mol⁻¹.
- Intended for biochemical and pharmacological research applications.
- Storage: powder at -20°C; in solvent -80°C (up to 6 months) or -20°C (up to 1 month).
ABclonal Technology Cullin 3 Rabbit pAb
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Apexbio Technology LLC 7-Deaza-7-Propargylamino-dATP 10ul (100 mM)
7-Deaza-7-Propargylamino-dATP is a chemically modified nucleotide analog derived from deoxyadenosine triphosphate It is designed to enable enzymatic incorporation by DNA polymerases during DNA synthesis thereby facilitating site-specific labeling of DNA 7-Deaza-7-Propargylamino-dATP exerts its biological activity primarily through incorporation into nascent DNA strands introducing a terminal propargyl group that serves as a reactive alkyne handle for conjugation reactions via click chemistry approaches Based on these pharmacological properties 7-Deaza-7-Propargylamino-dATP holds research potential in DNA labeling fluorescent probe generation and studies of DNA polymerase activity specificity and DNA damage detection and repair mechanisms in molecular biology and biomedical research