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Short/small hairpin RNA (shRNA) is an artificial RNA molecule with a tight hairpin turn used to silence target gene expression via RNA interference (RNAi). Cells can be made to express shRNA through the introduction of plasmids or viral/bacterial vectors.
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The OriGene Technologies TR30021V5 is a lentiviral control particle that functions as a negative control in shRNA experiments, featuring a GFP label for easy visualization. Engineered with a puromycin resistance gene, it allows efficient selection of transduced mammalian cells. This product aids in optimizing multiplicity of infection (MOI), providing researchers with essential tools for successful gene delivery.
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This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma.
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The protein encoded by this gene is a member of the dual specificity protein kinase family which acts as a mitogen-activated protein (MAP) kinase kinase MAP kinases also known as extracellular signal-regulated kinases (ERKs) act as an integration point for multiple biochemical signals This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals As an essential component of MAP kinase signal transduction pathway this kinase is involved in many cellular processes such as proliferation differentiation transcription regulation and development
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The protein encoded by this gene is a serine threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome as well as with skin pancreatic and testicular cancers
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