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Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
MW 413.9 Da, Purity >98%. Water soluble, cell-permeable p38 MAPK inhibitor. Shows selectivity over many other kinases but also shown to have some inhibitory activity against GAK, CK1 , RIP2 c-Raf and GSK3.
MW 398.4 Da, Purity >99%. Selective cell-permeable inhibitor of casein kinase 1 (CK1) . (IC₅₀ values are 0.3 (CK1), 0.5 (ALK5), 9.1 (PKd1) and 5.8 μM (p38αMAPK)). Displays selectivity over many other protein kinases.
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This gene encodes a member of the tripartite motif (TRIM) family The TRIM motif includes three zinc-binding domains a RING a B-box type 1 and a B-box type 2 and a coiled-coil region The encoded protein is part of the RoSSA ribonucleoprotein which includes a single polypeptide and one of four small RNA molecules The RoSSA particle localizes to both the cytoplasm and the nucleus RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference The encoded protein is highly basic and contains a PAZ domain and a PIWI domain It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing Multiple transcript variants encoding different isoforms have been found for this gene
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Disuccinimidyl glutarate is a homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker that couples primary amines via a glutarate spacer. It is used in antibody-drug conjugate synthesis, protein and peptide crosslinking, and surface or bead immobilization in research applications. The compound is supplied at high purity for laboratory use.
Amine-reactive NHS ester groups enable efficient coupling of primary amines.