siRNA
ABclonal Technology KO Validated SMARCB1/SNF5
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures allowing the transcriptional machinery to access its targets more effectively The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase This gene has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors Alternatively spliced transcript variants have been found for this gene
ABclonal Technology PI3 Kinase p110 beta
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K) These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB) PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection Alternative splicing results in multiple transcript variants
ABclonal Technology KO Validated CDK4 Rabbit
The protein encoded by this gene is a member of the Ser Thr protein kinase family This protein is highly similar to the gene products of S cerevisiae cdc28 and S pombe cdc2 It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression The activity of this kinase is restricted to the G1-S phase which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a) This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) Mutations in this gene as well as in its related proteins including D-type cyclins p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers Multiple polyadenylation sites of this gene have been reported
ABclonal Technology KO Validated TRIM21/SS-A
This gene encodes a member of the tripartite motif (TRIM) family The TRIM motif includes three zinc-binding domains a RING a B-box type 1 and a B-box type 2 and a coiled-coil region The encoded protein is part of the RoSSA ribonucleoprotein which includes a single polypeptide and one of four small RNA molecules The RoSSA particle localizes to both the cytoplasm and the nucleus RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined
HORIZON DISCOVERY BIOSCIENCES LIMITED HUMAN HCN2 610 SIRNA - SMART
NC3055350 HUMAN HCN2 610 SIRNA - SMART
HORIZON DISCOVERY BIOSCIENCES LIMITED HUMAN P2RY10 27334 SIRNA - S
NC3055354 HUMAN P2RY10 27334 SIRNA - S
ABclonal Technology KD Validated Gelsolin
The protein encoded by this gene binds to the plus ends of actin monomers and filaments to prevent monomer exchange The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments Defects in this gene are a cause of familial amyloidosis Finnish type (FAF) Multiple transcript variants encoding several different isoforms have been found for this gene
ABclonal Technology PI3 Kinase p85 alpha/beta
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85 55 or 50 kD This gene encodes the 85 kD regulatory subunit Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin and a mutation in this gene has been associated with insulin resistance Alternative splicing of this gene results in four transcript variants encoding different isoforms [provided by RefSeq Jun 2011]
ABclonal Technology PI3 Kinase p85 alpha/beta
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85 55 or 50 kD This gene encodes the 85 kD regulatory subunit Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin and a mutation in this gene has been associated with insulin resistance Alternative splicing of this gene results in four transcript variants encoding different isoforms [provided by RefSeq Jun 2011]