Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Quantity
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631
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631
Tocris Bioscience™ Psoralen-triethylene glycol azide
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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RNA conformation probe; reagent for COMRADES RNA platform
632
Tocris Bioscience™ aTAG 4531
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Degrader of MTH1 fusion proteins for use within the aTAG system
633
Tocris Bioscience™ GSK 2795039
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Small and Specialty Supplier Partner
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NADPH oxidase 2 (NOX2) inhibitor
| Target | NADPH Oxidase Inhibitors |
|---|---|
| CAS | 1415925-18-6 |
| Purity | 0.98 |
| Chemical Name or Material | N-[3-(2,3-Dihydro-1-methyl-1 H-indol-6-yl)-1-(1-methylethyl)-1 H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1 H-pyrazole-3-sulfonamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C23H26N6O2S |
634
Tocris Bioscience™ PPM-3
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Potent and selective ERK5 Degrader (PROTAC™)
635
Tocris Bioscience™ GF-AFC
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Cell permeable fluorogenic substrate cleaved by cytosolic aminopeptidases for non-lytic high throughput cell viability assays
636
Tocris Bioscience™ MYX 1715
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N-myristoyltransferase (NMT) inhibitor
638
Tocris Bioscience™ PFI 7
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Selective GID4 antagonist
| Target | Ubiquitin Ligase (E3) Inhibitors |
|---|---|
| Purity | 0.98 |
| Chemical Name or Material | N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H27N5O.2HCl |
639
Tocris Bioscience™ MLN 4924
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable
| Target | NEDD8 Activating Enzyme E1) |
|---|---|
| CAS | 905579-51-3 |
| Purity | 0.98 |
| Chemical Name or Material | [(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C21H25N5O4S |
640
Tocris Bioscience™ RU.521
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
| Target | Synthase/Synthetase Inhibitors |
|---|---|
| CAS | 2262452-06-0 |
| Purity | 0.98 |
| Chemical Name or Material | 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H12Cl2N4O3 |
641
| CAS | 256373-96-3 |
|---|---|
| Molecular Formula | C20H23N2NaO5S |
642
Tocris Bioscience™ MSC 1186
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective SRPK family inhibitor
| Target | SRPK3/STK23 |
|---|---|
| CAS | 2871698-23-4 |
| Purity | 0.98 |
| Chemical Name or Material | N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H17ClFN7O2S |
643
Tocris Bioscience™ CHS 828
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NAMPT inhibitor; active in vivo and cytotoxic
| CAS | 200484-11-3 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H22ClN5O |
| Formula Weight | 371.86 |
644
Tocris Bioscience™ Belinostat
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent pan-HDAC inhibitor
| Target | Histone Deacetylase Inhibitors |
|---|---|
| CAS | 866323-14-0 |
| Purity | 98% |
| Chemical Name or Material | (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C15H14N2O4S |
645
Tocris Bioscience™ TL 13-27
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Negative control for TL 12-186