Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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76
Tocris Bioscience™ MK 2206 dihydrochloride
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Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
| Target | Akt (Protein Kinase B) Inhibitors |
|---|---|
| CAS | 1032350-13-2 |
| Purity | 0.98 |
| Chemical Name or Material | 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C25H21N5O.2HCl |
77
Tocris Bioscience™ EM 12-FS
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Molecular glue; induces degradation of NQAT1
| Target | Molecular Glues |
|---|---|
| CAS | 2839138-44-0 |
| Purity | 0.95 |
| Chemical Name or Material | 3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C13H11FN2O6S |
78
Tocris Bioscience™ SAK 3
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Potent CaV3.1/3.3 activator; orally bioavailable
| Target | Cav3.x Channel Activators |
|---|---|
| CAS | 1256269-87-0 |
| Purity | 98% |
| Chemical Name or Material | Ethyl 8′-methyl-2′,4-dioxo-2-(piperidin-1-yl)-2′H-spiro[cyclopent[2]ene-1,3′-imidazo[1,2-a]pyridine]-3-carboxylate |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H23N3O4 |
79
Tocris Bioscience™ CID 1375606
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GPR27 agonist
| CAS | 313493-80-0 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H14Cl2N2O2 |
80
Tocris Bioscience™ TL 13-27
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Negative control for TL 12-186
81
Tocris Bioscience™ MSC 1186
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Potent and selective SRPK family inhibitor
| Target | SRPK3/STK23 |
|---|---|
| CAS | 2871698-23-4 |
| Purity | 0.98 |
| Chemical Name or Material | N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H17ClFN7O2S |
82
Tocris Bioscience™ Ambrisentan
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Selective ETA antagonist
83
Tocris Bioscience™ BDY FL, SE
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Small and Specialty Supplier Partner
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Green BDY (BODIPY™ or boron-dipyrromethene) fluorescent dye for the labeling of amines; supplied as NHS ester
84
Tocris Bioscience™ O8 OGG1 Inhibitor
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Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay)
| CAS | 350997-39-6 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C9H6Cl2N2OS |
| Formula Weight | 261.13 |
85
Tocris Bioscience™ CHS 828
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NAMPT inhibitor; active in vivo and cytotoxic
| CAS | 200484-11-3 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H22ClN5O |
| Formula Weight | 371.86 |
86
Tocris Bioscience™ GSK 9311 Hydrochloride
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Negative control for GSK 6853
| Purity | 98% |
|---|---|
| Chemical Name or Material | N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxybenzamide hydrochloride |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C24H31N5O3.HCl |
| Formula Weight | 474 |
87
Tocris Bioscience™ SJ 1008066
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MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
88
Tocris Bioscience™ GSK 583
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Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable
| CAS | 1346547-00-9 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H19FN4O2S |
89
Tocris Bioscience™ PSEM 308 hydrochloride
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PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
| Target | Pharmacologically Selective Effector Molecules/PSEM |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 5-Methyl-5,8,9,10,11 A,12-hexahydro-4 H-8,11-ethanopyrido[3 ',2 ':3,4 ]diazepino[6,7,1-hi]indole hydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C17H21N3.HCl |
| Formula Weight | 303.83 |
90
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Thermo Scientific Chemicals Etodolac
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Thermo Scientific Chemicals Etodolac
CAS: 41340-25-4 Molecular Formula: C17H21NO3
| CAS | 41340-25-4 |
|---|---|
| Molecular Formula | C17H21NO3 |