Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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1,156
Tocris Bioscience™ ML 179
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Selective liver receptor homolog 1 (LRH1) inverse agonist
| CAS | 1883548-87-5 |
|---|---|
| Product Type | Bioactive Small Molecule |
| Solubility | Soluble to 50mM in DMSO |
| Purity | >99% |
| Physical Form | Crystalline Solid |
| Chemical Name or Material | ML 179 |
| Recommended Storage | Store at 4°C |
| Synonym | 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione |
| Molecular Formula | C21H25F3N4O2 |
| Formula Weight | 422.44 |
1,157
Tocris Bioscience™ Pomalidomide 4'-PEG5-acid
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Cereblon ligand with PEG linker and terminal acid for onward chemistry
1,158
Tocris Bioscience™ HTMT dimaleate
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CAS: 195867-54-0 Molecular Formula: C27H37F3N4O9
| CAS | 195867-54-0 |
|---|---|
| Molecular Formula | C27H37F3N4O9 |
1,159
Tocris Bioscience™ C 176
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mSTING antagonist
| Target | STING Antagonists |
|---|---|
| CAS | 314054-00-7 |
| Purity | 97% |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C11H7IN2O4 |
1,160
Tocris Bioscience™ CP 100356 hydrochloride
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CAS: 142715-48-8 Molecular Formula: C31H37ClN4O6
| CAS | 142715-48-8 |
|---|---|
| Molecular Formula | C31H37ClN4O6 |
1,161
Tocris Bioscience™ Opicapone
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COMT inhibitor
| Target | Catechol O-Methyltransferase (COMT) Inhibitors |
|---|---|
| CAS | 923287-50-7 |
| Purity | 0.98 |
| Chemical Name or Material | 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C15H10Cl2N4O6 |
1,162
Tocris Bioscience™ CGP 60474
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Potent cdk inhibitor
| Target | Cyclin-dependent Kinase Inhibitors |
|---|---|
| CAS | 164658-13-3 |
| Purity | >98% |
| Chemical Name or Material | 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C18H18ClN5O |
| Formula Weight | 355.82 |
1,163
Tocris Bioscience™ A 1331852
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Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
1,164
Tocris Bioscience™ Z-Guggulsterone
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Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)
| Inhibitors | Z-Guggulsterone |
|---|---|
| Product Type | Z-Guggulsterone |
| Molecular Weight (g/mol) | 312.45 |
| Purity | >98% |
1,165
Tocris Bioscience™ BSJ-03-204
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Selective Cdk4/6 degrader
1,166
Tocris Bioscience™ AZD 6482
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CAS: 1173900-33-8 Molecular Formula: C22H24N4O4
| CAS | 1173900-33-8 |
|---|---|
| Molecular Formula | C22H24N4O4 |
1,167
Tocris Bioscience™ Nutlin 3a
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MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
| CAS | 675576-98-4 |
|---|---|
| Chemical Name or Material | 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C30H30Cl2N4O4 |
| Formula Weight | Observed MW: 581.49 |
| Assay Percent Range | >97% |
1,168
Tocris Bioscience™ 5-BDBD
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Potent and selective P2X4 antagonist
| Inhibitors | 5-BDBD |
|---|---|
| Product Type | 5-BDBD |
| Molecular Weight (g/mol) | 355.19 |
| Purity | >99% |
1,169
Tocris Bioscience™ SJ 6986
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Molecular glue; induces degradation of GSPT1/2
| Target | Molecular Glues |
|---|---|
| CAS | 2765625-93-0 |
| Purity | 0.98 |
| Chemical Name or Material | N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C20H14F3N3O7S |
1,170
Tocris Bioscience™ Telenzepine dihydrochloride
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CAS: 147416-96-4 Molecular Formula: C19H24Cl2N4O2S
| CAS | 147416-96-4 |
|---|---|
| Molecular Formula | C19H24Cl2N4O2S |