Protein Modification Reagents
Medchemexpress LLC DBCO-mPEG | 00-00-0 | 98.4% | 10MG
DBCO-mPEG is a DBCO-functionalized methoxy-polyethylene glycol (mPEG) reagent with an average molecular weight of 5,000 Da. Supplied as a white to light yellow solid for research use, it enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) to conjugate azide-containing molecules and serves as a spacer or linker in bioconjugation and PROTAC synthesis.
- Enables copper-free click chemistry (SPAAC) with azide-containing partners.
- Provides a methoxy-terminated PEG spacer with average MW 5,000 Da.
- Supplied as a solid with high reported purity (~98.4%).
- Suitable for bioconjugation, linker construction, and PROTAC applications.
- Stable when stored at -20°C under inert atmosphere; in solution, store at -80°C for long-term.
eMolecules Mal-PEG2-acid | Broadpharm | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 0.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196
Mal-PEG2-acid | Broadpharm | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 0.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196
Medchemexpress LLC Dmg-peg 2000 | 160743-62-4 | 98.4% | 2000 (Average) | 50 MG
DMG-PEG 2000 is utilized in the preparation of liposomes for siRNA delivery, enhancing transfection efficiency in vitro. It is also employed for lipid nanoparticles in an oral plasmid DNA delivery approach in vivo, through surface modification, to improve mucus permeability and delivery efficiency of the nanoparticles.
- Used for liposome preparation for siRNA delivery with improved transfection efficiency in vitro.
- Used for lipid nanoparticles for oral plasmid DNA delivery with improved mucus permeability and delivery efficiency in vivo.
Medchemexpress LLC Mal-PEG2-gly-gly-phe-gly-exatecan | 1599439-54-9 | 98.6% | 1149.18 | C57H65FN10O15 | 5 MG
A drug-linker conjugate used in antibody-drug conjugate (ADC) synthesis and cancer research. It consists of an exatecan payload linked via a maleimide-PEG2-gly-gly-phe-gly linker. For research use only.
- Suitable for antibody-drug conjugate synthesis
- High purity: 98.6%
- Molecular weight: 1149.18 g/mol
- Chemical formula: C57H65FN10O15
- Soluble in DMSO
- Store at -20°C and protect from light
eMolecules Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Medchemexpress LLC Mal-PEG4-PFP ester | 1415800-42-8 | MFCD28556926 | 95.4% | 511.39 g/mol | C21H22F5NO8 | 250 MG
Mal-PEG4-PFP ester is a noncleavable antibody-drug conjugate (ADC) linker composed of a maleimide group, a four-unit polyethylene glycol (PEG4) spacer, and a pentafluorophenyl (PFP) ester reactive group. It is supplied as a viscous liquid for research use only and is not intended for therapeutic use.
- Noncleavable ADC linker suitable for conjugation strategies.
- Maleimide group enables thiol-selective conjugation.
- PFG ester (pentafluorophenyl) is reactive toward amines for efficient coupling.
- PEG4 spacer increases solubility and provides distance between conjugated components.
- High purity (95.4%) for research applications.
- Molecular weight 511.39 g/mol and formula C21H22F5NO8.
- Appearance viscous liquid, off-white to light brown.
- Recommended storage: pure form -20°C for long term; in solvent store cold as specified.
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2,835.50 g/mol | C149H224N22O32 | 50 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a DBCO reactive group with a cleavable valine-citrulline linker, a p-aminobenzyl self-immolative spacer, and dual MMAE payloads. It is supplied as a purified powder for use in bio-conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a DBCO reactive group for copper-free click chemistry (SPAAC).
- Includes a PEG2 spacer for improved solubility and flexibility.
- Features a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer.
- Contains two MMAE payloads for potent cytotoxic delivery.
- High purity, typically 99.2%.
- Supplied as a powder suitable for ADC construction and conjugation.
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 5 MG
Biotin-PEG4-PFP ester is a biotinylated, cleavable PEG-based linker containing a pentafluorophenyl activated ester for efficient coupling to primary amines. It is used in antibody-drug conjugate (ADC) synthesis, PROTAC linker construction, and the biotinylation of proteins or small molecules. The reagent is supplied as a powder and requires low-temperature storage to maintain stability.
- Biotinylated PEG4 spacer with pentafluorophenyl activated ester.
- Suitable for coupling to primary amines in proteins and small molecules.
- Used as an ADC and PROTAC linker or biotinylation reagent.
- High purity and defined storage conditions for stability.
- Available in small milligram quantities for research use.
Medchemexpress LLC T-Boc-N-amido-PEG5-tosylate | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 g/mol | C22H37NO9S | 1 G
A Boc-protected PEG5 tosyl linker for chemical conjugation and linker assembly. The reagent combines a hydrophilic five-unit polyethylene glycol spacer with a tosylate leaving group and a Boc-protected amine, providing improved solubility and enabling nucleophilic substitution for installation of PEG-based linkers in medicinal chemistry and bioconjugation workflows.
- Enhances aqueous solubility via PEG5 spacer.
- Enables nucleophilic substitution through tosylate leaving group.
- Protects primary amine with Boc for selective deprotection.
- Suitable for linker assembly and bioconjugation chemistry.
- Compatible with standard organic synthesis conditions.
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(PEG2000) (ammonium salt) | 474922-26-4 | 99.96% | 2790.52 | (C2H4O)nC44H87N2O10P.NH3 | 5MG
DSPE-PEG(2000) Amine is an amine-terminated PEGylated phospholipid used to functionalize liposomes and lipid nanoparticles for surface conjugation and targeted delivery. The hydrophobic DSPE tail anchors the molecule in lipid bilayers, while the PEG2000 spacer provides steric stabilization and improved colloidal stability; the terminal primary amine enables covalent coupling to activated esters, dyes, linkers, or targeting ligands.
- Amine-terminated PEGylated phospholipid for surface functionalization.
- Hydrophobic tail anchors stably in lipid bilayers.
- Peg spacer provides steric stabilization and reduces aggregation.
- Terminal primary amine enables covalent coupling chemistries.
- Offered as an ammonium salt in powder and solution forms.
- High purity suitable for research use (supplier-stated ~99.96%).
- Store at -20°C; soluble in chloroform:methanol mixtures.
Medchemexpress LLC Dspe-peg-oh | 99.89% | 100 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and its hydroxyl terminus is suitable for further reactions. DSPE-PEG-OH (MW 2000) can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid.
- Hydrophobic tail enables encapsulation and aggregation of other hydrophobic drugs.
- Hydroxyl terminus suitable for further reactions.
- Can be used to prepare liposomes or lipid nanoparticles.
Medchemexpress LLC Tetraglyme | 143-24-8 | 99.93% | 222.28 | 500 G
Me-PEG4-Me is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is for an E3 ubiquitin ligase and the other for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Is a peg-based protac linker
- Useful in the synthesis of protacs
Medchemexpress LLC DMG-PEG-Mal (MW 2000) | 99.3% | 2000 (Average) | 100 MG
DMG-PEG-Mal (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. It is suitable for use in drug delivery research.
- Enhances delivery efficiency of poorly soluble drugs
- Improves tissue specificity of poorly soluble drugs
- Suitable for drug delivery research