Protein Modification Reagents
Medchemexpress LLC En219-alkyne | 99.6% | 488.76 g·mol⁻¹ | C22H19BrClN3O3 | 5 MG
EN219-alkyne is an alkyne-functionalized covalent probe designed to engage RNF114 and enable click-chemistry labeling and activity-based protein profiling. Supplied as a light brown solid with high purity, it provides a reactive alkyne handle for biochemical conjugation and target identification studies.
- High purity of 99.62%.
- Alkyne handle for click-chemistry conjugation.
- Targets RNF114 as a covalent ligand for activity profiling.
- Molecular formula C22H19BrClN3O3 and molecular weight 488.76 g·mol⁻¹.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store sealed at -20°C; in solution store at -80°C for long-term stability.
![Medchemexpress LLC L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-... | 2052306-13-3 | 98.2% | 1093.18 g/mol | C53H74BrN9O9S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264323.png-250.jpg)
Medchemexpress LLC L-Prolinamide, N-[2-[3-[4-[3-[4-[[5-bromo-4-[[3-[(cyclobutylcarbonyl)methylamino]propyl]amino]-... | 2052306-13-3 | 98.2% | 1093.18 g/mol | C53H74BrN9O9S | 5 MG
PROTAC TBK1 degrader-2 is a small-molecule PROTAC that binds and induces degradation of TANK-binding kinase 1 (TBK1). It shows potent biochemical and cellular activity and is intended for target validation and mechanism-of-action studies in research settings.
- Potent degradation of TBK1 (DC50 = 15 nM).
- High binding affinity to TBK1 (Kd = 4.6 nM).
- Low-nanomolar inhibitory activity (IC50 TBK1 = 1.3 nM; IKKε = 8.7 nM).
- High reported purity suitable for research (98.2%).
- White to off-white solid with good DMSO solubility (110 mg/mL).
- Intended for cellular and biochemical PROTAC studies and target validation.
Sigma Aldrich Fine Chemicals Biosciences Proteinase K recombinant P
Proteinase K is a subtilisin-related serine protease. The recombinant enzyme is identical to the native protease originally isolated from the mold Tritirachium album. The specifications of the recombinant enzyme are the same as those of the native protease. The amino acid sequence (molecular weight) and the molecule structure are identical. However the recombinant preparation is much purer than the native enzyme as it is DNA-free that has no pronounced cleavage specificity. The enzyme is extremely effective on native proteins and can therefore be used to rapidly inactivate endogenous nucleases such as RNases and DNases. The enzyme is also available as a SOLUTIONon.Inhibitors The enzyme is inactivated by Pefabloc(R) SC. However it is not inactivated by metal ions chelating agents (e.g. EDTA) sulfhydryl reagents or trypsin and chymotrypsin inhibitors.Activators Proteinase K activity is stimulated by the presence of denaturing agents (SDS and urea).pH Optimum Proteinas
Medchemexpress LLC Propargyl-PEG4-O-C1-NHS ester | 1161883-51-7 | 100 MG
Propargyl-PEG4-O-C1-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing azide groups.
- Target PROTAC linkers
- Part of the PROTAC pathway
- Functions as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition
- Used in the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
STA PHARMACEUTICAL US LLC Fmoc-amino-PEG3-CH2COOH | 100 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC THP-PEG4-Pyrrolidine(N-Me)-CH2OH | 2378261-81-3 | 95.0% | 50 MG
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker. This compound is used in the synthesis of PROTACs, which are molecules designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs achieve this by connecting two ligands: one for an E3 ubiquitin ligase and another for the target protein, offering a novel approach in biological activity modulation.
- Functions as a PROTAC linker
- Facilitates selective protein degradation
- Useful for biological research applications
- Available with comprehensive documentation
