Protein Modification Reagents
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 250 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed with two ligands, one for an E3 ubiquitin ligase and another for the target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Functions as a PEG-based PROTAC linker
- Enables synthesis of PROTACs
- Utilizes the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC DBCO-PEG6-NHS ester | 95.0% | 737.79 | 50 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions. It reacts efficiently to form covalent bonds. DBCO-PEG6-NHS ester also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Contains an NHS ester that reacts specifically with primary amines.
- Reacts under neutral or slightly alkaline conditions.
- Forms covalent bonds.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Medchemexpress LLC Azide-peg4-tos | 168640-82-2 | 99.6% | C15H23N3O6S | 100 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker for PROTAC synthesis. It acts as a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups, or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs use two linked ligands, one targeting an E3 ubiquitin ligase and the other a protein of interest, to selectively degrade proteins via the ubiquitin-proteasome system.
- Peg-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with azide group
- Undergoes CuAAc with alkyne groups
- Participates in SPAAC with DBCO or BCN groups
- PROTACs: two linked ligands
- Targets E3 ubiquitin ligase and protein of interest
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | >=98.0% | 557.55 g/mol | C24H35N3O12 | 1 G
Mal-amido-PEG5-C2-NHS ester is a non-cleavable PEG-based linker containing a maleimide and an N-hydroxysuccinimide (NHS) ester for conjugation to thiol and amine groups in proteins, peptides, and oligonucleotides. It is commonly used in antibody-drug conjugate (ADC) synthesis and other bioconjugation research applications.
- Contains maleimide and NHS ester functional groups
- Non-cleavable PEG-based linker for bioconjugation
- CAS number 1315355-92-0
- Molecular weight 557.55 g/mol
- Formula C24H35N3O12
- Appearance viscous liquid, colorless to light yellow
- Purity >=98.0%
- Storage pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month)
- Available in 1 G package