Protein Modification Reagents
Thermo Scientific Production Chemicals and Services DOE AND INGALLS
NC3985134 GUANIDINE HYDROCLRIDE 99. 500G
Medchemexpress LLC PROTAC MDM2 Degrader-1 | 2249944-98-5 | 98.1% | 1 MG
PROTAC MDM2 Degrader-1 (Compound 15a) is an MDM2 PROTAC degrader. The structures of both linker ends are MDM2 ligands. This compound can block the binding of p53-MDM2 and also degrade the target MDM2 protein by utilizing the E3 ligase function of MDM2 itself, thereby exhibiting an anti-tumor effect. It is intended for research use only.
- MDM2 PROTAC degrader
- Blocks the binding of p53-MDM2
- Degrades the target MDM2 protein
- Exhibits anti-tumor effect
- Intended for research use only
Medchemexpress LLC PROTAC EGFR degrader 8 | 2925923-46-0 | C40H46CIN11O5 | 5 MG
PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. It degrades EGFR in HCC827 cells with a DC50 of 15.56 nM and inhibits the growth of H1975, PC-9, and HCC827 cells with IC50s of 7.72 nM, 121.9 nM, and 14.21 nM, respectively. It can be utilized for cancer research, particularly NSCLC.
- Degrades EGFR in HCC827 cell with a DC50 of 15.56 nM
- Inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM
- Used for research of cancer, especially NSCLC
Medchemexpress LLC PROTAC EGFR degrader 7 | 3033297-59-2 | 99.99% | 836.94 | 5 MG
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. It inhibits NCI-H1975 cells proliferation with an IC50 of 46.82 nM. This product significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cells and shows antitumor activity, making it suitable for non-small cell lung cancer (NSCLC) research. Additionally, it is a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader
- Inhibits NCI-H1975 cells proliferation
- Induces apoptosis and G2/M phase arrest in NCI-H1975 cells
- Shows antitumor activity for non-small cell lung cancer (NSCLC) research
- Click chemistry reagent containing an Alkyne group
Medchemexpress LLC Protac EGFR degrader 3 | 2768472-28-0 | 97.4% | 1092.40 | C60H77N13O5S | 5 MG
PROTAC EGFR degrader 3 is a proteolysis-targeting chimera designed to selectively induce degradation of the epidermal growth factor receptor (EGFR) in cellular assays. It is intended for research use to study EGFR signaling and degradation mechanisms; molecular formula C60H77N13O5S and molecular weight 1092.40. Available in small pack sizes for screening and exploratory experiments.
- Selective EGFR degradation in cellular models.
- Demonstrated cellular activity in EGFR-dependent cell lines.
- Suitable for cell-based studies of EGFR signaling and degradation mechanisms.
- Available in small research pack sizes for screening and exploratory work.
- High reported purity suitable for biochemical and cellular assays.
Medchemexpress LLC Protac MDM2 degrader-2 | 2249944-99-6 | MFCD32197289 | 96.0% | 1391.22 g/mol | C70H76Cl4N10O12 | 5 MG
PROTAC MDM2 Degrader-2 is a bifunctional small molecule degrader designed to recruit an E3 ligase to MDM2, promoting ubiquitination and proteasomal degradation of MDM2. The compound leads to p53 stabilization and shows antiproliferative effects in cellular assays. It is supplied for research use with characterized purity, formula, and storage recommendations.
Sigma Aldrich Fine Chemicals Biosciences Guanidine thiocyanate >=97% (titration) | 593-84-0 | MFCD00013027 | 1KG
Guanidine thiocyanate >=97% (titration) | Purity: >=97% (titration) | Mol Wt: 118.16 | 593-84-0 | MFCD00013027 | 1KG