Immunohistochemistry Kits and Reagents
Medchemexpress LLC Discoidin domain receptor 1 (DDR1), rat recombinant protein (HEK293, His-tag) | >95.0% | 500 UG
Recombinant rat discoidin domain receptor 1 (DDR1) expressed in HEK293 cells with a C-terminal His tag. This purified protein is designed for biochemical and cell-based studies of collagen-mediated signaling, matrix remodeling, and protein-protein interactions. Purity is reported as greater than 95% by reducing SDS-PAGE, and multiple size formats are available, including a 500 μg option.
- HEK293-expressed rat DDR1 with C-terminal His tag.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Available in multiple sizes, including a 500 μg format.
- Suitable for biochemical and cell-based assays.
- Useful for studying collagen-mediated signaling, matrix remodeling, and receptor interactions.
ABclonal Technology Cortactin Rabbit mAb
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Medchemexpress LLC DDR1 protein, mouse, HEK293-expressed, C-terminal His-tag | >95.0% | 50 UG
Recombinant mouse Discoidin Domain Receptor 1 (DDR1) fragment (D20-T414) expressed in HEK293 cells and supplied as a C-terminal His-tagged solution in PBS. The protein is purified (>95% by reducing SDS-PAGE), 0.22 μm filtered, and provided in amounts including a 50 μg vial. Store at -80°C and ship on dry ice. Suitable for biochemical assays and antibody validation.
- Species: mouse
- Expression system: HEK293 cells
- Tag: C-terminal His
- Sequence range: D20-T414 (accession Q03146-2)
- Purity: >95% by reducing SDS-PAGE
- Formulation: 0.22 μm filtered PBS, pH 7.4, solution
- Storage: store at -80°C; shipped on dry ice
- Applications: binding assays, antibody validation, and cell signalling studies
Enzo Life Sciences 8(S)-Hydroxyeicosa-5Z,9E,11Z,14Z-tetraenoic acid (HETE) (50µg). CAS: 98462-03-4
Biosynthesis in human neutrophils, phorbol ester-treated mouse epidermis and by hepatic microsomal cytochrome P-450. Chemotactic for neutrophils. Activator of PPARα. Activates mouse skin protein kinase C (PKC). Alternative name: 8(S)-HETE. Formulation: Liquid. In ethanol. Purity: ≥99% (HPLC). Long Term Storage: -80°C.
Biotium Cytokeratin 8(B22.1), Biotin conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant)
Biotium Ksp-Cadherin / CDH16 (Renal Cell Marker)(CDH16/2448), Biotin conjugate, 0.1mg/mL
This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exce
Biotium Napsin A (Lung Adenocarcinoma Marker)(NAPSA/1865R), Biotin conjugate, 0.1mg/mL
Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Leica Biosystems PV POLY-AP ANTI MOUSE IGG 110M
PowerVision Poly-AP Anti-Mouse IgG is biotin-free, polymeric alkaline phosphatase (AP) conjugate, for the manual detection of tissue-bound mouse antibodies.
