Immunohistochemistry Kits and Reagents
IBL America Complement System MBL Pathway
The Wieslab COMPL MP320 kit is an enzyme immunoassay for the determination of MBL complement pathway in human serum. For research use only, not for use in diagnostic procedures.
Biotium Desmin (Muscle Cell Marker)(D33), Biotin conjugate, 0.1mg/mL
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. Primary antibodies are available purified, or with a selection of fluorescent CF
Biotium Complement C4d(C4D205), CF594 conjugate, 0.1mg/mL
This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, a
Abcam TripleStain IHC Kit: M&R&G on human tissue (DAB, AP/Red & HRP/Green), 18ML
Abcam's TripleStain IHC Kit (ab183290) is designed to be used with user-supplied one goat, one mouse and one rabbit primary antibodies to detect three distinct antigens on a single human tissue or cell samples.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical p38 MAPK InhIbItr IV 25mg
An ATP-competitive inhibitor of p38 MAPKs; inhibits p38α, p38β, p38��, and p38δ MAPKs (IC50s = 0.13, 0.55, 5.47, and 8.63 μM, respectively); inhibits LPS-induced TNF-α and IL-1β cytokine production in human peripheral blood mononuclear cells (IC50s = 22 and 44 nM, respectively)
Biotium Cytokeratin 8 (KRT8)(KRT8/2115), Biotin conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ('ring-like, perinuclear') from ductal ('peripheral-predominant')
Electron Microscopy Sciences IHC Retriever Section Block 125 ML
A new class of blocking solutions based on chemically modified and fragmented ultra-pure casein. Effectively reduces unwanted binding of primary antibody and conjugates you use to charged surface of the slide and tissue section. Greatly reduces non-specific binding while preserving the specific reaction, by saturating potential non-specific protein-protein interactions. Moreover, in contrast to BSA-based, IgGm casein or serum - based blocking solutions there is no interaction of specific antibody and blocking protein itself. or oth Is not comparable to other commercially available or home-made blocking solutions. Recommended for research and diagnostic pathology, especially for retrieved sections and polyclonal antibodies.
Biocare Medical, LLC Immunocare TBS Wash Buffer, 10X
Immunocare TBS Wash Buffer (sodium azide and thimerasol free) works well for manual and automated immunohistochemistry applications as well as other laboratory procedures requiring a high quality TBS buffer with superior pH stability. The buffer contains surfactant and allows for reagents to spread more uniformly across tissue sections on slides. It has been specifically formulated with Enzyme Activator for Alkaline Phosphatase detection systems. It can also be used on an automated staining system.
Biotium Human Kappa Light Chain(L1C1), CF594 conjugate, 0.1mg/mL
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can gi
Biocare Medical, LLC MACH 2 Double Stain 2 - 25 ml
The conjugated goat anti-mouse polymer horseradish peroxidase (HRP) and the conjugated goat anti-rabbit polymer alkaline phosphatase (AP) secondary antibodies react with both heavy and light chains on mouse and rabbit IgG respectively. This innovative HRP- and AP-polymerization technology provides a significant increase in staining sensitivity when compared to other conventional HRP- or AP-conjugated secondary antibodies. Avidin-biotin blocking procedures are not necessary when using the MACH 2 conjugated secondary antibodies. It is specially designed for a rapid double stain procedure. An antibody cocktail with a mouse monoclonal and a rabbit polyclonal/monoclonal must be used. The overall staining procedure can be done with 4 major steps and in less than two hours. It can be used manually or used with automated stainers.
ABclonal Technology δ-Catenin/p120 Catenin Rabbit pAb
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
Meso Scale Discovery RPLEX MSE Periostin/OSF2 ASYQP
The R-PLEX Mouse Periostin (OSF-2) Assay from Meso Scale Discovery is a multiplex immunoassay that measures periostin (OSF-2) in mouse samples such as serum plasma and cell culture supernatants This assay utilizes MSD s electrochemiluminescence (ECL) detection technology and provides high sensitivity a wide dynamic range and requires a low sample volume The assay can be fully automated and has a rapid 2 5 hour turnaround time It is available as a singleplex assay that measures only periostin or as a multiplex assay that measures periostin along with other analytes This assay allows the quantitative measurement of periostin which plays a role in cardiac remodeling and bone metabolism
Biotium CD4(C4/206), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 55 kDa, identified as CD4. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low