General Cell Based Assays
Cayman Chemical SOD asy RadIcal Detectr 1ea
An inhibitor of Kv1.3 and Kv1.4 (IC50s 0.23 and 0.3 UM respectively) selective for these channels over Kv1.1 Kv1.2 Kv1.5 and Kv1.6 channels (IC50s 62 14 19 and 20 UM respectively) as well as Kv3.1 Kv3.2 Kv3.4 and Kv4.2 channels (IC50s 17 10 36 and >10 UM respectively) inhibits anti-CD3 antibody- or ionomycin- and PMA-induced thymidine incorporation in isolated human peripheral blood T cells (IC50s 4.7 and 5.2 UM respectively)
Cayman Chemical NFAT InhIbItr 1mg
A peptide inhibitor of NFAT; binds to the NFAT recognition site on calcineurin (IC50 = 25 pM) but does not inhibit calcineurin phosphatase activity at 100 µM; inhibits the dephosphorylation of NFAT in HEK293T lysates expressing NFAT1, -2, or -4; inhibits NFAT activation in RAW 264.7 macrophages, EA.hy926 endothelial cells, and isolated mouse thoracic aorta VSMCs (IC50s = 29.1, 30.2, and 45.7 µM, respectively, in reporter assays)
Molecular Devices Cell Integrity Kit, Fluorescent, Live/Dead, 96- and 384-Well
The Molecular Devices EarlyTox Cell Integrity Kit R8214 is a fluorescence-based assay for rapid differentiation of live and dead cells using complementary nuclear dyes. The bulk kit is formulated for high-throughput imaging in 96- and 384-well plates and supports a homogeneous mix-and-read workflow with an optional masking reagent for improved signal.
- Sufficient for ten 96-well plates (approximately 960 wells) or equivalent 384-well plates.
- Contains two nuclear dyes for live and dead cell discrimination and masking reagent for homogeneous assays.
- Assay principle based on membrane permeability detection for live/dead identification.
- Compatible with adherent and non-adherent cell types and high-throughput imaging workflows.
- Recommended plate types: black-well, clear-bottom plates for imaging.
American Research Products Inc Rat inositol 1 4 5 trispho
Rat inositol 1 4 5 -trisphosphate (IP3) ELISA kit from CUSABIO Detection Range 5 pg/mL-1000 pg/mL Sensitivity 2 5 pg/mL Sample serum plasma tissue homogenates cell culture supernates cell lysates Method Competitive
Genscript Corporation ToxinSensor Single Tests Kit
GenScript ToxinSensor Single Tests Kit with Standard is designed to be a qualitative In Vitro end-point endotoxin test for human and animal parenteral drugs biological products and medical devices Tachypleus Amebocyte Lysate (TAL) as supplied is to be reconstituted with sample or control directly After incubation for 1 hour and in the presence of endotoxin gelation occurs in the absence of endotoxin gelation does not occur GenScript supply a series of ToxinSensorTM Single Tests Kits with Standard with different sensitivity (0 03 EU/ml 0 06 EU/ml 0 125 EU/ml and 0 25 EU/ml)
Eurofins Discoverx PathHunter eXpress EDNRB Total Internalization Assay, 10pl Kit. (93-0874E3CP0L)
The PathHunter EDNRB Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of EDNRB via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged EDNRB and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the EDNRB receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-Rb (Ser807/811) Detection Kit, 500 Assay Points
HTRF Human & Mouse Phospho-Rb (Ser807/811) Detection Kit, 500 Assay Points
ABclonal Technology Pyruvate carboxylase (PC) Rabbit mAb
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5 UTRs, but encoding the same protein, have been found for this gene.
Cayman Chemical RXR RetInoId X receptr100uL
A KCC2 cotransporter activator (EC50 616 nM for chloride transport in NG108-cl cells) selective for KCC2 over GABAA receptors at 50 UM increases the rate of chloride accumulation in spinal slices isolated from a rat model of PNI and BDNF control slices increases mechanical withdrawal thresholds in a rat model of PNI and reverses morphine-induced hyperalgesia in rats at 100 mg/kg
Abcam Urea Assay Kit
Urea Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Molecular Devices FLIPR Calcium Assay Kit, Express, Fluorescent, 96/384/1536-Plate
The FLIPR Calcium 6 Express Kit is a fluorescence-based, homogeneous reagent set for detecting intracellular calcium flux in high-throughput screening. The kit delivers an enhanced signal window and improved resistance to organic anion transporters, reducing the need for probenecid and enabling robust GPCR and ion channel assays across 96-, 384-, and 1536-well formats.
- Enhanced signal window for improved assay sensitivity.
- Homogeneous fluorescence format for simplified workflows.
- Reduced need for probenecid due to dye resistance to organic anion transporters.
- Supplies sufficient reagent for approximately 100 96- or 384-well plates, or 150 1536-well plates.
- Store reagents at -20°C; aliquots may be frozen for short-term use.
Medchemexpress LLC TrkC Human HEK293 50ug
TrkC Protein a receptor tyrosine kinase crucially contributes to nervous system and potential heart development Upon NTF3/neurotrophin-3 binding TrkC undergoes autophosphorylation activating pathways like phosphatidylinositol 3-kinase/AKT and MAPK These pathways regulate cell survival and differentiation emphasizing TrkC s pivotal role in essential cellular processes during development TrkC Protein Human (HEK293 His) is the recombinant human-derived TrkC protein expressed by HEK293 with C-His labeled tag
Revvity Health Sciences Inc HTRF Human Phospho-IRF3 (Ser386) Detection Kit, 10,000 Assay Points
HTRF Human Phospho-IRF3 (Ser386) Detection Kit, 10,000 Assay Points
Meso Scale Discovery U-PLEX Mouse IP-10 ASY 25 PL
The Meso Scale Discovery U-PLEX Mouse IP-10 Assay is a multiplex immunoassay kit that enables simultaneous quantitative measurement of mouse interferon gamma-induced protein 10 (IP-10) in serum plasma and cell culture supernatants It utilizes electrochemiluminescent detection technology on patterned arrays for high sensitivity and broad dynamic range The assay requires 50 L or less sample volume and can be read on the MESO QuickPlex SQ 120 instrument The kit includes a 96-well plate coated with capture antibodies detection antibodies calibrators and ancillary reagents needed to run the assay