General Cell Based Assays
MOLTOX Molecular Toxicology Inc 60-250.5 - NADPH REGENSYS A Plus. 50ml refers to final volume of S9 mix/pkg. Intended for use in EAT testing. Supports 5-30% S9 mix. G-6-P MgCl2-KCL in 0.1M phosphate buffer. pH 7.4. Add to B Plus. Refrigerate.
60-250.5 - NADPH REGENSYS A Plus. 50ml refers to final volume of S9 mix/pkg. Intended for use in EAT testing. Supports 5-30% S9 mix. G-6-P MgCl2-KCL in 0.1M phosphate buffer. pH 7.4. Add to B Plus. Refrigerate.
Cayman Chemical RXR RetInoId X receptr100uL
An inhibitor of PI3K and PI3KY (IC50s 24.5 and 33.2 nM respectively) greater than 300- and 120-fold selective for PI3K and PI3KY respectively over PI3Ka and PI3KB induces cell death in L-540 KM-H2 and L-428 cells at 10 UM induces cell cycle arrest at the G0/G1 phase in the same cells reduces tumor growth and vasculature induces tumor necrosis and induces the M1 phenotype in TAMs in an L-540 mouse xenograft model
American Research Products Inc Bevacizumab Biosimilar
Bevacizumab Biosimilar (Anti-VEGFA) Antibody is a biosimilar antibody with human reactivity produced in humanized Available in 100 ug size with 7 - 14 business days lead time Ships via gel pack Store at -20 C to -80 C for 12 months in lyophilized form After reconstitution if not intended for use within a month aliquot and store at -80 C (Avoid repeated freezing and thawing) Lyophilized antibodies are shipped at ambient temperature
American Research Products Inc Rat tissue inhibitors of metal
Rat tissue inhibitors of metalloproteinase 2 TIMP-2 ELISA Kit from CUSABIO Detection Range 1 25 ng/mL-80 ng/mL Sensitivity 0 31 ng/mL Sample serum plasma tissue homogenates Method Sandwich
Eurofins Discoverx PathHunter eXpress OXGR1 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0693E2CP1M)
The PathHunter OXGR1 (GPR80, GPR99) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of OXGR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OXGR1 and EA-tagged β-Arrestin-2. Activation of OXGR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress EDNRB Total Internalization Assay, 10pl Kit. (93-0874E3CP0L)
The PathHunter EDNRB Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of EDNRB via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged EDNRB and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the EDNRB receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress SYK Activity Assay, 10-Plate Kit. (93-0865E3CP16L)
The PathHunter eXpress SYK Activity Assay is a stable, engineered cell line for use in studying small molecule drug candidates targeting the SYK kinase domain. The cell line is engineered to express the catalytic domain from SYK fused to the cytokine receptor binding domain (CRBD) of JAK2. The cells co-express an Enzyme Acceptor (EA) tagged SH2 domain and a ProLink (PK) tagged Cytokine receptor. The CRBD is designed to bind the CTK catalytic domain to the GHR-PK. Activation of the GHR-PK induces receptor phosphorylation by the SYK catalytic domain. This leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IFNRL1/IL10RB Dimerization Assay, 2pl Kit. (93-0993E3CP5M)
The PathHunter IFNRL1/IL10RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-29) induced dimerization of IFNRL1/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IFNRL1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IFNRL1/IL10RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress BMPR1B/ACVR2A Dimerization Assay, 10pl Kit. (93-1010E3CP0L)
The PathHunter BMPR1B/ACVR2A Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. BMP-6) induced dimerization of BMPR1B/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses BMPR1B target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of BMPR1B/ACVR2A, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IFNRL1/IL10RB Dimerization Assay, 10pl Kit. (93-0993E3CP5L)
The PathHunter IFNRL1/IL10RB Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-29) induced dimerization of IFNRL1/IL10RB receptors. This product uses EFC technology. The cell line included overexpresses IFNRL1 target protein fused to PK alongside IL10RB target protein fused to EA. Upon ligand-induced dimerization of IFNRL1/IL10RB, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GHR-JAK1 Functional Assay, 2-Plate Kit. (93-0756E3CP0M)
The PathHunter GHR-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses GHR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged GHR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress rGPR120 CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-1031E2RCP0L)
The PathHunter rGPR120 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. free fatty acids) based activation of rGPR120 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rGPR120 and EA-tagged β-Arrestin-2. Activation of rGPR120 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress P2RY4 Activated GPCR Internalization Assay, 10pl Kit. (93-0741E3CP0L)
The PathHunter P2RY4 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of P2RY4 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged P2RY4. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting P2RY4-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GHR-JAK1 Functional Assay, 10-Plate Kit. (93-0756E3CP0L)
The PathHunter GHR-JAK1 Functional assay eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting CTKs. This kit assesses GHR activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged GHR cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.