General Cell Based Assays
Eurofins Discoverx cAMP Hunter eXpress PTGER2 DLD1 GPCR Assay, 2-Plate Kit. (95-0176E13CP25M)
The cAMP Hunter PTGER2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGER2, a naturally Gs coupled GPCR. Upon activation of PTGER2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical Glycogen phsphoylase InHBI 1mg
A cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM); blocks glucagon-induced hepatic glycogenolysis in vivo
Cytek Biosciences Inc Mu TBNK Myeloid Treg Kit P
Product Name: Cytek Tonbo Mouse TBNK/Myeloid/Treg Kit
Cytek Catalog Number: 95-K001-T025
Product Class: Kits and Panels
Type: Panel
Size: 25 Tests
Cayman Chemical CellBased Assay Buffer Tablet
Cell-Based Assay Buffer Tablet has been formulated and tested to work with Cayman’s Assay Kits. Detailed instructions for its use are contained in the respective Cayman Assay Kit booklet.
Cayman Chemical ALT asy Cofactr 1ea
A Cdk9 inhibitor (IC50 6 nM) selective for Cdk9 over Cdk1-8 (IC50s 397->10000 nM) and Cdk12-19 (IC50s 372->10000 nM) induces cell cycle arrest at the G1 phase and apoptosis in BT-20 BT-549 MDA-MB-231 MT-3 and Hs 578T TNBC cells from 0.64-7.73 UM reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg
Cayman Chemical LPO asy FTS Reagent 1 1ea
A medium-chain acyl CoA inhibitsbutyryl-CoAacetate-CoA transferase isolated from P. elsdenii at 200 UM levels are increased in primary fibroblasts derived from patients with MCAD deficiency in the presence of heptanoic acid blocks berberine-induced decreases in infarct volume and improvements in motor function in a mouse model of MCAO-induced ischemic stroke at 0.4 mg/kg per day
STEMCELL Technologies Atazanavir, Size: 25 mg
Inhibit HIV-1 protease with atazanavir (IC50 2 - 5 nM Wood). Atazanavir an azapeptide binds to HIV-1 protease and prevents it from producing viral proteins rendering the virus non-infectious as no mature virions are made when HIV-1 protease is inhibited (Kohl et al.). Atazanavir is also a substrate and an inhibitor of cytochrome P450 isozyme 3A (CYP3A) and an inducer of P-glycoprotein (Perloff et al.).
Meso Scale Discovery Human/NHP IgG Kit, 1 plate
Immunoglobulins (Ig) are critical components of the immune system and play a major role in eliciting immune response against pathogens. Five heavy-chain isotypes (IgA, IgD, IgE, IgG, and IgM) mediate specific biological functions, including responses to pathogens and immunological diseases such as allergy and autoimmune disorders. IgG, a monomer, is the dominant immunoglobulin class present in serum. There are four subclasses of IgG, namely IgG1, IgG2, IgG3, and IgG4. IgG is commonly used as a diagnostic tool for humoral immunodeficiencies, autoimmune diseases, liver diseases, chronic inflammatory diseases, haematological disorders, infections, and lymphoid malignancies. This kit provides the assay-specific components for the quantitative determination of IgG in human, cynomolgus monkey, and rhesus monkey samples.
Enzo Life Sciences Matrix Metalloproteinase-13 (MMP-13) fluorometric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-13 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-13 (MMP-13, collagenase-3) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-13, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Alternative name: Collagenase 3. Applications: Fluorescent detection, HTS Activity assay.
Meso Scale Discovery RPLEX HUM Fcepsilon RII ASY
The R-PLEX Human FC Epsilon RII Assay Kit from Meso Scale Discovery measures free human IgE in samples like serum and plasma This electrochemiluminescent immunoassay uses MSD s SULFO-TAG labels and multi-array plate technology for sensitive reproducible results similar to ELISA The kit includes a 96-well plate with anti-human IgE capture antibody SULFO-TAG labeled detection antibody assay diluent read buffer wash buffer and calibrator Sensitivity is 0 24 ng/mL with an upper quantitation limit of 1500 ng/mL IgE