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CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment CD14 can be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein
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Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development
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An inhibitor of Cdk1 (IC50 = 5.8 µM); selective for Cdk1 over Cdk5 and GSK3β (IC50s = 25 and >100 µM, respectively); inhibits HeLa cell proliferation (IC50 = 2 µM)
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MW 389.4 Da, Purity >99%. Potent and selective H3K27 histone demethylase inhibitor (IC₅₀ = 60 nM, JMJD3). Inhibits UTX. Some activity for the H3K4me3/2/1 demethylases Jarid1b and Jarid1c (IC₅₀ values are 950 nM and 1.76 μM, respectively). No significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Anti-inflammatory effects.
MW 349.3 Da, Purity >98%. Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC₅₀ = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro. See similar compound .