Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700
The Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 controls the biological activity of Rab7. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ Smad3 Inhibitor, SIS3
Smad3 Inhibitor, SIS3, CAS 1009104-85-1, is a cell-permeable, selective inhibitor of TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated signaling. Does not affect Smad2, MAPK, ERK, or PI3-K.
MilliporeSigma™ Calbiochem™ Sodium Salicylate
A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.
MilliporeSigma™ Calbiochem™ SREBP Processing Inhibitor, Betulin
The SREBP Processing Inhibitor, Betulin, also referenced under CAS 473-98-3, controls the biological activity of SCAP (SREBP cleavage activating protein). This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ TAPI-1
TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.
MilliporeSigma™ Calbiochem™ SRT1720
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56μM; Km = 2.44μM), but NAD+-uncompetitive (Ki = 0.34μM; Km = 280μM).
MilliporeSigma™ Calbiochem™ Pamidronate, Disodium Salt
A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.
MilliporeSigma™ Calbiochem™ TLR1/TLR2 Agonist II, CU-T12-9
A diphenyl substituted imidazole based compound that directly and selectively targets TLR1/2 and induces their dimerization and activates TLR1 and 2 signaling leading to NF-κB and AP-1 activation ( K D = 182 and 478 nM, respectively; EC50
MilliporeSigma™ Calbiochem™ Ro-32-0432
A selective cell-permeable protein kinase C inhibitor.
MilliporeSigma™ Calbiochem™ Honokiol
A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.
MilliporeSigma™ Calbiochem™ PPACK II, Trifluoroacetate Salt
Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
MilliporeSigma™ Calbiochem™ JAK2 Inhibitor X, FLLL32
A cell permeable analog of curcumin that acts as a specific inhibitor of JAK2 (≈5 μM) and blocks STAT3 phosphorylation in MDA-MB-231 and PANC-1 cancer cells.
MilliporeSigma™ Calbiochem™ Cdk4 Inhibitor
The Cdk4 Inhibitor, also referenced under CAS 546102-60-7, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ Caspase-8 Inhibitor II
The InSolution™ Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Cathepsin L Inhibitor IV
The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.