Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ (+)-Bicuculline
A potent allosteric antagonist of vertebrate GABAA recept
MilliporeSigma™ Calbiochem™ Keap1-Nrf2 Interaction Probe, ML334
A cell-permeable, direct, non-covalent inhibitor of Keap1 - Nrf2 protein - protein interaction (Kd = 1 μM) that causes the dissociation of Nrf2 from keap1 in the cytosol.
MilliporeSigma™ Calbiochem™ Flumazenil
A competitive blocker of benzodiazepine activation of inhibitory GABAergic synpases (ID50 = 200μg/kg/i
MilliporeSigma™ Calbiochem™ IKKε/TBK1 Inhibitor II, MRT67307
A cell-permeable, potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKKε (IC50 = 19 and 160 nM, respectively).
MilliporeSigma™ Calbiochem™ Cyclopamine-KAAD
Cyclopamine- KAAD, CAS 306387-90-6, is a cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM).
MilliporeSigma™ Calbiochem™ InSolution™ CXCR4 Antagonist I, AMD3100
InSolution™ CXCR4 Antagonist I, AMD3100, CAS 155148-31-5, is a 50 mM (15 mg/308 μL) solution of CXCR4 Antagonist I, AMD3100 (Cat. No. 239820) in H2O.
MilliporeSigma™ Calbiochem™ L-N5-(1-Iminoethyl)ornithine, Dihydrochloride
A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.
MilliporeSigma™ Calbiochem™ Importazole
A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.
MilliporeSigma™ Calbiochem™ HIF-1α Translation Inhibitor, KC7F2
The HIF-1α Translation Inhibitor, KC7F2, also referenced under CAS 927822-86-4, controls the biological activity of HIF-1α. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ IKK-2 Inhibitor, SC-514
The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ Glucose Transporter Inhibitor IV, WZB117
The Glucose Transporter Inhibitor IV, WZB117 controls the biological activity of Glucose Transporter.
MilliporeSigma™ Calbiochem™ HIF-Hydroxylase Inhibitor, DMOG
The HIF-Hydroxylase Inhibitor, DMOG, also referenced under CAS 89464-63-1, controls the biological activity of HIF-Hydroxylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Ciglitazone
A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC50 = 3 μM).
MilliporeSigma™ Calbiochem™ Chymotrypsin Substrate II, Fluorogenic
Sensitive fluorogenic substrate for the quantitative determination of chymotrypsin activity.
MilliporeSigma™ Calbiochem™ MCT1 Inhibitor, SR13800
A cell-permeable inhibitor of monocarboxylate transporter 1 (MCT1). Blocks the proliferation of Raji Burkitt lymphoma cells expressing MCT1 (EC50 = 5 nM).