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Cocktails, tablets, capsules, and individual purified formulations of protease inhibitors and phosphatase inhibitors designed to protect proteins from degradation during cell lysis and extraction.
The Xpert Protease Inhibitor Cocktail Solution(100X) is a specially formulated mixture of 5 protease inhibitors with broad specificity for the inhibition of various protease and esterase.
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Cathepsin-L inhibitor. Potent, selective and reversible inhibitor of human cathepsin L (IC50=1.9nM). Inhibits release of Ca2+ and hydroxyproline from bone in vitro. Alternative name: N-(1Naphthalenylsulfonyl)- IW-CHO. Formula: C27H29N3O4S. MW: 491.6. Purity: ≥97% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO or ethyl acetate (50mg/ml). Long Term Storage: -20°C.
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PF-07321332 is an orally active covalent inhibitor of the 3C-like protease by direct binding of the catalytic cysteine 145. 3CL protease cleaves polyproteins 1a and 1ab of SARS-CoV-2, a step required for reproduce the virus. The PF-07321332/ritonavir combination drug (trade name Paxlovid) is efficient for the treatment of COVID-19 as, in November 2021, Pfizer announced phase 2/3 clinal trial results that the drug treatment reduced 89% in hospitalizations when given within three days after symptom onset. This product is for research use only.
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AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
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