Protease Inhibitors and Phosphatase Inhibitors
Bioassay Systems EnzyFluo™ MMP-1 Inhibitor Assay Kit, For evaluation of drugs and screening of potential inhibitors to MMP-1.
MATRIX METALLOPROTEINASE-1 or MMP-1 (EC 3.4.24.7) is a Ca2+– and Zn2+-dependent, interstitial collagenase that plays a role in the remodeling of the extracellular matrix of tissues. MMP-1 is up-regulated in metastatic cancer cells and in rheumatoid arthritis. BioAssay Systems’ EnzyFluo™ MMP-1 Inhibitor Assay Kit uses a quenched synthetic substrate. Upon digestion by MMP-1, the substrate is cleaved, which abolishes the quenching of the fluorescence label. The fluorescent fragment is measured at λex/em = 490/520 nm. Inhibition is determined by the decrease in fluorescence.
Echelon Biosciences Research Labs BODIPY TMR-PTDINS(3)P 100 ug
BODIPY TMR PI(3)P (BODIPY TMR Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the orange fluorophore, Bodipy-TMR, at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate (PI(3)P) is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Biocare Medical, LLC MELANOMA COCKTAIL 6ML
Melanoma Cocktail is a combination of HMB45 and MART-1, which are coexpressed in the majority of melanomas, as well as solely expressed in certain cases. This cocktail is potentially a sensitive first-order pan melanoma screener.
Apexbio Technology LLC selective EGFR inhibitor 153436-53-4. MFCD00270914
selective EGFR inhibitor 153436-53-4. MFCD00270914
Echelon Biosciences Research Labs Cathepsin B Substrate - 10 mg, CAS#: 100900-19-4
Cathepsin B Substrate - 10mg , Z-Arg-Arg-4-methoxy-2-naphtylamide Category/Application: Enzyme Substrates This item is non returnable
Echelon Biosciences Research Labs Cathepsin B Substrate - 25 mg, CAS#: 100900-19-4
Cathepsin B Substrate - 25mg , Z-Arg-Arg-4-methoxy-2-naphtylamide Category/Application: Enzyme Substrates This item is non returnable
Echelon Biosciences Research Labs Akt Substrate - 5 mg,
Akt Substrate - 5mg , Arg-Pro-Arg-Ala-Ala-Thr-Phe-NH2 Category/Application: Enzyme Substrates This item is non returnable
Echelon Biosciences Research Labs HIV Substrate IV - 1 mg,
HIV Substrate IV - 1mg , Lys-Ala-Arg-Val-Nle-Phe(NO2)-Glu-Ala-Nle-NH2 Category/Application: Enzyme Substrates This item is non returnable
Cayman Chemical JAK2 InhIbItr V 10mg
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM; blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F
Cayman Chemical STOML3 InhIbItr OB-1 10mg
An inhibitor of STOML3 oligomerization; inhibits oligomerization of mouse and human STOML3 in cell-free assays at 10 µM; reduces Piezo1 channel current amplitude in Neuro2a cells; inhibits tactile perception in wild-type mice and reduces tactile allodynia in a mouse model of streptozotocin-induced diabetic neuropathy
Echelon Biosciences Research Labs Caspase Substrate - 5 mg,
Caspase Substrate - 5mg , Ac-Ala-Glu-Val-Asp-AFC Category/Application: Enzyme Substrates This item is non returnable
Cayman Chemical ProstaglndIn D2 InhIbItr 5mg
A PGD2 receptor antagonist (DP; IC50 = 0.3 nM); inhibits PGD2-induced cAMP accumulation in LS 174T cells that endogenously express the DP receptor
Echelon Biosciences Research Labs SS14 Tumor Inhibitor Analog - 1 mg,
SS14 Tumor Inhibitor Analog - 1mg , D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 Category/Application: Neuropeptides Hormones This item is non returnable
Enzo Life Sciences Cystatin C (human), (purified) (100 µg)
Alternative name: Cystatin 3, Neuroendocrine basic polypeptide, CysC. Purity: ≥95% (SDS-PAGE). Formulation: Lyophilized from 0.02M ammonium bicarbonate buffer. Source: Isolated from human urine. Long Term Storage: -20°C.
Cayman Chemical PRL-3 InhIbItr 10mg
A cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases; reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay