Protease Inhibitors and Phosphatase Inhibitors
Abcam Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor
Potent, broad-spectrum MMP inhibitor
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC HY-116716 5mg Medchemexpress, PIN1 inhibitor API-1 CAS:680622-70-2 Purity:>98%
Medchemexpress, HY-116716 5mg PIN1 inhibitor API-1 CAS:680622-70-2 PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical GLS1 InhIbItr 1mg
An inhibitor of GLS1 (IC50 = 0.021 μM); inhibits the growth of NCI H1703 NSCLC cells in vitro (GI50 = 0.011 μM); reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model at 100 mg/kg
Selleck Chemical LLC BIBF-0775 S2234-5mg
BIBF-0775 is a selective inhibitor of transforming growth factor Receptor I (TGF RI Alk5) with an IC50 of 34nM
Abcam Paro x etine hydrochloride, 5-HT uptake inhibitor, 50MG
MW 365.8 Da, Purity >99%. Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
The product is subject to the following: Abcam Restricted Use Statement
TARGETMOL CHEMICALS INC BRM BRG1 ATP Inhibitor-1 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 uM). Purity 99.84%
CPC Scientific H-Abz-Gly-Pro-DLeu-DAla-NH-OH (trifluoroacetate salt) 0.5MG
Inhibitor of human matrix metalloproteinases that maintains its activity even after prolonging incubation with pronase or human granulocyte elastase. It also inhibits interstitial and granulocyte collagenases, granulocyte gelatinase and skin fibroblast stromelysin with IC50 of 1 x 10-6 M, 3 x 10-5 M and 1.5 x 10-4 M, respectively.SEQUENCE: H-Abz-Gly-Pro-DLeu-DAla-NH-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: Abz-GP-DLeu-DAla-NH-OHMOLECULAR FORMULA: C23H35N6O6MOLECULAR WEIGHT: 490.55STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [124168-73-6]SYNONYMS: 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOHRESEARCH AREA: CancerREFERENCES:S. Odake, et al., Biochem. Biophys. Res. Commun. 199, 1442 (1994)SKU(s): MMPS-001A, MMPS-001B
Medchemexpress LLC NSC668394 100mg | 382605-72-3 | 452.1 g/mol | C17H12Br2N2O3 | 100 MG
NSC668394 is a small-molecule inhibitor of ezrin Thr567 phosphorylation offered for research use. It is supplied as an orange to red solid with molecular formula C17H12Br2N2O3, molecular weight 452.1 g/mol, and reported purity of 99.31%. The compound is available in multiple pack sizes, including 100 MG, and has recommended storage conditions for powder and solutions to preserve stability.
- Inhibits ezrin Thr567 phosphorylation for cellular and biochemical studies.
- High reported purity (99.31%) suitable for research applications.
- Orange to red solid physical form for easy handling.
- Molecular weight 452.1 g/mol; formula C17H12Br2N2O3.
- Available in multiple pack sizes, including 100 MG.
- Powder storage: -20°C for long-term stability; in solvent: -80°C recommended for extended storage.
- For research use only; not for human or veterinary use.
Abcam Serine Protease Assay Kit (FAM-Leu-DAP), 100 Tests
These Serine Protease Assay Kits enable researchers to detect intracellular chymotrypsin-like serine protease activity in vitro without lysing the cell.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Motesanib
Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM 3 nM 6 nM 8 nM 84 nM 59 nM for VEGFR1 VEGFR2 VEGFR3 Kit PDGFR and Ret respectively
Abcam (-)-Nutlin-3, p53-MDM2 binding inhibitor, 5MG
MW 581.5 Da, Purity >98%. Potent p53-MDM2 binding inhibitor (IC50 = 90 nM). Enantiomer of (+)-Nutlin-3 (ab144426). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical mP InhIbItr II 5mg
A reversible, broad-range inhibitor of MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM)
Medchemexpress LLC B I09 10mg | 1607803-67-7 | 10MG
B I09 is an IRE-1 RNase inhibitor with an IC50 of 1230 nM
Selleck Chemical LLC KU-55933 (ATM Kinase Inhibitor) 5mg 587871-26-9
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU?55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy?initiating kinase ULK1 and results in a significant decrease of autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical Cdk4 InhIbItr 5mg
A cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 = 0.8 μM); inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest