Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Apoptosis Activator III, Embelin
The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Hydroxychloroquine Sulfate
A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC50 = 30 μM).
MilliporeSigma™ Calbiochem™ Elastase Substrate IV, Colorimetric
A specific substrate for pancreatic elastase.
MilliporeSigma™ Calbiochem™ SecinH3
A cell-permeable triazolo compound that acts as a Sec7 domain-binding, selective antagonist against cytohesin family small GEFs.
MilliporeSigma™ Calbiochem™ APT1 Inhibitor II, Cpd21
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma pr
Novus Biologicals™ Vismodegib Hedgehog inhibitor
May be dissolved in DMSO (200 mg/mL); or ethanol (10 mg/mL, warm)
MilliporeSigma™ Calbiochem™ ALLN
ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
MilliporeSigma™ Calbiochem™ Cathepsin D/E Substrate, Fluorogenic
An internally quenched fluorogenic 11-mer peptide that acts as a sensitive and selective substrate for cathepsins D and E, but not cathepsins B, H, or L .
MilliporeSigma™ Calbiochem™ D-Amino Acid Oxidase Inhibitor II, CBIO
The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.
MilliporeSigma™ Calbiochem™ 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt
Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.
MilliporeSigma™ Calbiochem™ GSK-3β Inhibitor I
The GSK-3β Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Staurosporine, N-Benzoyl
A cell-permeable Staurosporine derivative that displays antitumor properties.
MilliporeSigma™ Calbiochem™ 4-Hydroxyphenylretinamide
A synthetic amide of all-trans retinoic acid (RA) that displays reduced toxicity relative to RA while maintaining significant biological activity.
MilliporeSigma™ Calbiochem™ β-Glycerophosphate, Disodium Salt, Pentahydrate
A phosphate group donor in matrix mineralization studies that acts as a protein phosphatase inhibitor.
MilliporeSigma™ Calbiochem™ Caspase Inhibitor VI
Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.