Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ PI 3-K Inhibitor XXI, GDC-0941
A cell-permeable, potent, ATP-competitive inhibitor of class IA (IC50 = 3 nM/p110α, 33 nM/p110β, 3 nM/p110δ) and IB PI 3-kinases (IC50 = 75 nM/p110γ).
MilliporeSigma™ Calbiochem™ 2',5'-Dideoxyadenosine
Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 μM), that binds to the adenosine P1 binding site.
MilliporeSigma™ Calbiochem™ SNC80
A very potent and selective δ opioid receptor agonist (IC50
MilliporeSigma™ Calbiochem™ Myricetin
A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties.
MilliporeSigma™ Calbiochem™ NFAT Inhibitor, MCV1
The NFAT Inhibitor, MCV1 controls the biological activity of NFAT.
MilliporeSigma™ Calbiochem™ TNF-α Inhibitor
The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.
MilliporeSigma™ Calbiochem™ Casein Kinase II Inhibitor III, TBCA
The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Pifithrin-α
A cell-permeable chemical inhibitor of p53.
MilliporeSigma™ Calbiochem™ ApoE4 Modulator, PH002
A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby reversing the detrimental effects of ApoE4.
MilliporeSigma™ Calbiochem™ APT1 Inhibitor II, Cpd21
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma pr
MilliporeSigma™ Calbiochem™ Hedgehog Antagonist VIII
The Hedgehog Antagonist VIII, also referenced under CAS 330796-24-2, controls the biological activity of Hedgehog. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ Myeloperoxidase Inhibitor-II
A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT ( K i
R&D Systems™ Pan Caspase OPH Inhibitor Q-VD, Non-omethylated
Cell-permeable, irreversible inhibitor of caspase activity. Q-VD-OPh does not exhibit toxic effects at typical working concentrations.
MilliporeSigma™ Calbiochem™ LRRK2 Inhibitor II, CZC-25146
The LRRK2 Inhibitor II, CZC-25146 controls the biological activity of LRRK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Mevastatin
An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation.