Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ CMP-Sialic Acid, Disodium Salt InSolution™
A 25 mM (10 mg/608 μL) sterile-filtered solution of CMP-Sialic Acid, Disodium Salt in H2O.
MilliporeSigma™ Calbiochem™ Cdk1 Inhibitor IV, RO-3306
RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
MilliporeSigma™ Calbiochem™ Hydroxyfasudil
A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties.
MilliporeSigma™ Calbiochem™ D-Amino Acid Oxidase Inhibitor II, CBIO
The D-Amino Acid Oxidase Inhibitor II, CBIO, also referenced under CAS 61977-29-5, controls the biological activity of D-Amino Acid Oxidase.
MilliporeSigma™ Calbiochem™ Protein Arginine N-Methyltransferase Inhibitor, AMI-1
The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ PKCθ/δ Inhibitor
A cell-permeable pyridinecarbonitrile compound that acts as a potent, ATP-competitive (Ki = 79 nM, using PKCθ KD in coupled PK/LDH assays), and isozyme-selective PKCθ inhibitor (IC50 = 70nM) with much reduced potency against other novel PKCs (IC50
MilliporeSigma™ Calbiochem™ PI 3-Kγ/CKII Inhibitor
The PI 3-Kγ/CKII Inhibitor, also referenced under CAS 1138220-19-5, controls the biological activity of PI 3-Kγ/CKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ JAK3 Inhibitor I
The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Calpain-1 Substrate II, Fluorogenic
An internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides.
MilliporeSigma™ Calbiochem™ α2-Antiplasmin, Human Plasma
A 452-amino acid glycoprotein present in plasma at about 70 μg/ml.
MilliporeSigma™ Calbiochem™ D-Val-Phe-Lys Chloromethyl Ketone, Dihydrochloride
Selective irreversible inhibitor of plasmin with high selectivity for plasmin (IC50 = 100 pM for human plasmin) over urokinase.
MilliporeSigma™ Calbiochem™ (±)-Ibuprofen
A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 μM).
MilliporeSigma™ Calbiochem™ Rac1 Inhibitor
Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC50 ≈50 μM).
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor V, Stattic
STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
MilliporeSigma™ Calbiochem™ MRN-ATM Pathway Inhibitor, Mirin
The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Rad50-Nbs1) complex. This small molecule/inhibitor is primarily used for Cell Structure applications.