Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Scopolamine Hydrobromide
A competitive, non-selective antagonist for muscarinic acetylcholine receptors (mAChR)
Cytiva Protease Inhibitor Mix
For effective protease inhibition during protein sample prep
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor II, SMIP004
A cell-permeable phenylacetamide compound that is shown to upregulate p21Cip1/Waf1 and/or p27Kip1 in prostate cancer LNCaP, PC3, DU145, but not HeLa, cultures (40μM for 24 h) with a concomitant downregulation of the F-box E3 ubiquitin ligase Skp2 and a delayed G1-to-S cell cycle transition, displaying no apparent effect toward cell cycle progression or p21 and p27 levels in non-cancer human fibroblast
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set VII
Protease Inhibitor Cocktail Set VII contains five protease inhibitors with broad specificity. Recommended for purification of proteins containing His·Tag™ sequences.
MilliporeSigma™ Calbiochem™ Apocynin
A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.
MilliporeSigma™ Calbiochem™ NBD-Binding Peptide II, Cell Permeable, CTP-NBD
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50∽ 50μM in HCT116 cells).
MilliporeSigma™ Calbiochem™ ERK Activation Inhibitor Peptide I, Cell-Permeable
The ERK Activation Inhibitor Peptide I, Cell-Permeable controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ TGF-β RI Kinase Inhibitor II, RepSox
A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4nM and 18nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively)
MilliporeSigma™ Calbiochem™ Fas/FasL Antagonist, Kp7-6
The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ SB 290157
A selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor. Does not antagonize C5aR or other chemotactic GPCRs.
MilliporeSigma™ Calbiochem™ InSolution™ Y-27632, Sterile-Filtered, Cell Culture-Tested
A 10 mM (2 mg/591 μL) sterile-filtered solution of Y-27632 in H2O.
MilliporeSigma™ Calbiochem™ Wortmannin
Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC50 = 5 nM). Does not affect any upstream signaling events.
MilliporeSigma™ Calbiochem™ Ciglitazone
A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC50 = 3 μM).
MilliporeSigma™ Calbiochem™ Adenosine A2A Receptor Antagonist II, SCH-58261
A highly potent and selective antagonist of adenosine A2A receptor (Ki = 6
MilliporeSigma™ Calbiochem™ TRPC3 Channel Inhibitor, Pyr3
The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.