Collagens
Cayman Chemical nospIramycIn I 10mg
A PI3K inhibitor (IC50 1 nM) selective for PI3K over PI3Ka PI3KB and PI3KY (IC50s 10000 nM for all) as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 UM inhibits primary human B cell proliferation (IC50 0.2 nM) and memory T cell cytokine production (IC50s 0.2-1.5 nM) inhibits the differentiation of naïve isolated human T cells into Th1 Th2 or Th17 T helper cells inhibits the proliferation of JeKo-1 Mino Rec-1 and JVM-2 lymphoma cells (IC50s 50s 2-8 nM) reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg reduces proteinuria lymphadenopathy and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögrens syndrome
Cayman Chemical IcarIsIde I 25mg
A muscarinic receptor antagonist (IC50s 2.9 2 and 1.7 nM for M1 M2 and M3 receptors respectively) inhibits acetylcholine-induced bronchospasm in anesthetized guinea pigs (EC50 68 g/ml) prevents increases in airway resistance in a rat model of cadmium inhalation-induced chronic pulmonary inflammation with airspace enlargement at 0.2 mg/20 ml aerosolized and reduces neutrophil counts and total cell numbers in BALF and airspace enlargement in lungs when administered in combination with formoterol
Cayman Chemical GypenosIde XVII 25mg
A phenylethanoid glycoside scavenges DPPH radicals (EC50 6.6 UM in a cell-free assay) inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 Ug/ml reduces increases in plasma ALT TNF-a IL-1B IL-16 and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury at 60 mg/kg prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and DOPAC levels in a mouse model of MPTP-induced Parkinsons disease improves motor performance in the rotarod test in the same model
Cayman Chemical BaccatIn III 10mg
A naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol inhibits aldose reductase (IC50 213 Ug/ml) proteasome activity and cancer cell proliferation
Cayman Chemical TubeImosIde I 50mg
An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC50 10 UM) by inhibiting the expression of MMP-9 profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through STAT3
Cayman Chemical GypenosIde XVII 10mg
A phenylethanoid glycoside scavenges DPPH radicals (EC50 6.6 UM in a cell-free assay) inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 Ug/ml reduces increases in plasma ALT TNF-a IL-1B IL-16 and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury at 60 mg/kg prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and DOPAC levels in a mouse model of MPTP-induced Parkinsons disease improves motor performance in the rotarod test in the same model
Cayman Chemical BacopasIde I 10mg
A flavoNd wth dverse bologcal actvtes reduces ApoB proten levels ACAT2 expresson and LDL degradaton n HepG2 cells from 10-200 UM nhbts gG-nducedBhexosamndase release from RBL-2H3 cells (C50 0 099 mg/ml) nhbts LPS-nduced NO producton and reduces levels of NOS L-6 and L-1B n BV-2 mcroglal cells nhbts passve cutaneous anaphylaxs n mce at 5 mg/kg reduces body weght loss colon shortenng and ulcer severty n a mouse model of TNBS-nduced ulceratve colts reduces cortcal and hppocampal neuronal apoptoss and ncreases tme spent n the target quadrant n the Morrs water maze n a mouse model of LPS-nduced neuronal nflammaton
Cayman Chemical AstragalosIde I 25mg
An anti-migraine agent binds to connexin43 hemichannels and inhibits ATP release in vitro during injury and reperfusion in a dose-dependent manner blocks trigeminal ganglion neuronal-satellite glial cell signaling and cortical spreading depression in vivo (10 mg/kg) increases the seizure threshold in MEST mice and rats (143 and 1192 respectively) blocks neurogenic plasma extravasation in a rat trigeminal nerve migraine model
ABclonal Technology p-PKC alpha/beta II-T638/T641
Protein kinase C (PKC) is a family of serine- and threonine-specific kinases activated by calcium and diacylglycerol PKC family members phosphorylate various protein targets and are involved in multiple cellular signaling pathways They also serve as receptors for phorbol esters tumor-promoting compounds Each PKC member has a distinct expression profile and role in cells The protein encoded by this gene is a PKC family member involved in B cell activation apoptosis endothelial cell proliferation and intestinal sugar absorption Studies in mice suggest it may also regulate neuronal functions and influence fear-induced behavior after stress Alternative splicing generates distinct isoforms of this gene
ABclonal Technology Pro-Collagen I/COL1A1
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone cornea dermis and tendon Mutations in this gene are associated with osteogenesis imperfecta types I-IV Ehlers-Danlos syndrome type VIIA Ehlers-Danlos syndrome Classical type Caffey Disease and idiopathic osteoporosis Reciprocal translocations between chromosomes 17 and 22 where this gene and the gene for platelet-derived growth factor beta are located are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of the growth factor Two transcripts resulting from the use of alternate polyadenylation signals have been identified for this gene
ABclonal Technology Pro-Collagen I/COL1A1
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone cornea dermis and tendon Mutations in this gene are associated with osteogenesis imperfecta types I-IV Ehlers-Danlos syndrome type VIIA Ehlers-Danlos syndrome Classical type Caffey Disease and idiopathic osteoporosis Reciprocal translocations between chromosomes 17 and 22 where this gene and the gene for platelet-derived growth factor beta are located are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of the growth factor Two transcripts resulting from the use of alternate polyadenylation signals have been identified for this gene
Chondrex Inc IMMUN MOUSE COL2, SOL, 1 MG
1 mg (2 mg/mL x 0.5 mL solution in 0.05M acetic acid) of mouse type II collagen purified from mouse sternal cartilage. Purity: >99% by SDS-PAGE analysis (free of pepsin and proteoglycans). Molecular Weight: 300 kDa. Intended for use as antigen for immunizing animals inced arthritis (CIA) model, a standard for collagen analysis by SDS-gel, or substrate for collagenase activity
Chondrex Inc IMMUN BOVINE COL2, PDR, 10 MG
10 mg (lyophilized) of bovine type II collagen purified from bovine articular cartilage. Purity: >99% by SDS-PAGE analysis (free of pepsin and proteoglycans). Molecular Weight: 300 kDa. Intended for use as antigen for immunizing animals in the collagen-induced arthritis (CIA) model, a standard for collagen analysis by SDS-gel, or substrate for collagenase activity.