Tissue Lysates
Cayman Chemical SynthetIc BufotalIn 1mg
A bufadienolide with cytotoxic and immunomodulatory activities; induces cell cycle arrest at the G1 phase and apoptosis in Hep3B cells from 0.13-1.13 µM; reduces autoantibody production, serum levels of TNF-α, IL-1β, IFN-γ, IL-22, and IL-17, and the number of splenic and lymph node Th17 cells, as well as increases saliva flow rates in a mouse model of experimental Sjörgren’s syndrome at 100 UG/kg; induces lethality in anesthetized dogs (LD50 = 0.36 mg/kg)
Cayman Chemical HIston H1-derIved PeptIdet 1mg
A peptide substrate for CRK3/CYC6; phosphorylated by CRK3/CYC6 and has been used in high-throughput screening assays for the identification of CRK3/CYC6 inhibitors
Cayman Chemical GymnmIc AcId I 1mg
A triterpene glycoside; inhibits glucose-induced phosphorylation of serine 70 on S6K1 and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases authophagy in MIN-6 pancreatic β cells at 5 UG/ml; has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.