This monoclonal antibody provides highly specific detection of Yersinia pestis, the etiologic agent of plague and a critical target in public‑health surveillance and biodefense research. Clone 105 recognizes a defined antigenic determinant on Y. pestis, delivering strong affinity and minimal cross‑reactivity with related Yersinia species. Its clean, reproducible signal supports ELISA, Western blotting, antigen‑capture assays, and rapid‑test development. MYPS‑55A‑105 enables sensitive detection in culture supernatants, environmental samples, and purified bacterial preparations, making it valuable for diagnostic assay design, pathogen monitoring, and studies examining virulence mechanisms. Consistent lot‑to‑lot performance ensures reliable results across diverse assay formats.