Substrates
Medchemexpress LLC Z-Ala-Arg-Arg-AMC | 90468-18-1 | 98.4% | 692.77 g/mol | C33H44N10O7 | 5 MG
Z-Ala-Arg-Arg-AMC is a fluorogenic peptide substrate for quantifying trypsin-like activity of the proteasome. Proteolytic cleavage releases 7-amino-4-methylcoumarin (AMC), producing a fluorescence signal used in biochemical and enzymatic assays.
- Generates a fluorescent AMC signal upon proteolytic cleavage.
- Designed for measuring trypsin-like proteasome activity.
- High purity (~98.4%) suitable for research assays.
- Supplied as a solid; soluble in DMSO at about 50 mg/mL with ultrasonic assistance.
- Store sealed, away from moisture, under recommended low-temperature conditions.
- Available in small research-scale quantities (mg scale).
Medchemexpress LLC Z-DEVD-AMC | 98.2% | 767.74 | 10 MG
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. It serves as a fluorescence reference standard for AMC-based enzyme substrates, including AMC-based caspase substrates.
- Selective caspase-3 substrate
- Measured by fluorescence spectrometry
- Functions as a fluorescence reference standard for AMC-based enzyme substrates
- Purity of 98.2%
- Molecular weight of 767.74
- White to off-white solid appearance
- Research use only
- Excitation wavelength of 390
- Emission wavelength of 480
Cayman Chemical Cbz-Gly-Pro-AMC 5mg
A fluorogenic substrate for prolyl endopeptidase; AMC is released upon enzymatic cleavage by prolyl endopeptidase and its fluorescence can be used to quantify prolyl endopeptidase activity; ex/em = 340-360/440-460 nm, respectively
Revvity Health Sciences Inc HTRF Biotin-APP-Eu cryptate (BACE1 substrate), 20,000 Assay Points
HTRF Biotin-APP-Eu cryptate (BACE1 substrate), 20,000 Assay Points
Medchemexpress LLC D-luciferin potassium | 115144-35-9 | 100.0% | 318.41 | C11H7KN2O3S2 | 250MG
D-Luciferin potassium is the potassium salt of D-luciferin, the natural substrate for firefly luciferase. In the presence of ATP and appropriate cofactors it undergoes enzymatic oxidation to produce rapid, proportional chemiluminescent light, making it suitable for reporter gene assays, cell viability measurements, and sensitive ATP detection. Supplied as a high-purity solid and available in multiple pack sizes for research use.
- High-purity potassium salt for reliable luminescent assays.
- Produces rapid, proportional chemiluminescent signal.
- Compatible with luciferase-based reporter and ATP assays.
- Supplied as a solid, stable form for storage and handling.
- Available in a range of pack sizes to suit experimental needs.
Cayman Chemical TrnsglutamInase asy Substr 1ea
Transglutaminase Assay Substrate 1 has been tested and formulated to work exclusively with Cayman’s Transglutaminase Activity Assay Kit (Item No. 702250).
Bioworld D-Luciferin, Potassium Salt, 50 mg
Produces bioluminescence when oxidized by firefly luciferase. Allows highly sensitive bioluminescent measurement. Specification:Water Soluble FormL-Luciferin: <0.5%Protect from light and mositureAppearance: Solid
Cell Signaling Technology ChIP-Grade Protein G Magnetic Beads 1 ml
ChIP-Grade Protein G Magnetic Beads 1 ml
eMolecules 2-(Aminomethyl)-5-nitrophenylboronic acid | 1217500-83-8 | MFCD12546495 | 1g
Combi-Blocks | 2-(Aminomethyl)-5-nitrophenylboronic acid | 1g | 117524247 | BB-5848 | 96.000 | 1217500-83-8 | MFCD12546495 | 195.970 | C7H9BN2O4
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Cayman Chemical ADHP Fluorescent
A highly sensitive, stable substrate for HRP that reacts with H2O2 to produce the fluorescent compound resorufin; enables detection of H2O2 at a concentration as low as 5 pmol per 100 µl samples
Bachem H-Glu-AMC
H-Glu-AMC, 98516-76-8, C15H16N2O5, Mr 304.30, 250mg. Substrate for aminopeptidase A.
Bachem H-Met-AMC
H-Met-AMC Acetate, 94367-34-7, C15H18N2O3S, Mr 306.39, 250mg. Fluorogenic substrate for methionine aminopeptidase 2, Km 0.31 ± 0.02 mM and kcat 3.3 ± 0.1 min-1 at pH 7.5 and 30°C.
Cayman Chemical HDAC8 Substrate 1ea
A PARP1 and PARP2 inhibitor (IC50s 50s 1-14.1 nM) inhibits the proliferation of Capan-1 cells (IC50 0.1 nM) as well as talazoparib- or olaparib-resistant Capan-1 cells (IC50s 1.13 and 0.89 nM respectively) inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 4.54 nM) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model at 12.5 and 25 mg/kg
Selleck Chemical LLC D-Luciferin
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications In an immunocompetent mouse model of ovarian cancer the use of D-luciferin substrate and firefly luciferase preserves tumour-host immune interactions since bioluminescent imaging is a more sensitive indication of tumour growth than weight gain