Isotopically Labeled Compounds
Medchemexpress LLC Diphenhydramine-d6 hydrochloride | 1189986-72-8 | 99.3% | 1 MG
Diphenhydramine-d6 hydrochloride is a deuterium labeled form of Diphenhydramine hydrochloride. It functions as a first-generation histamine H1-receptor antagonist with anti-cholinergic effects, capable of crossing the ovine blood-brain barrier (BBB). This compound is valuable as a tracer and an internal standard for quantitative analysis in techniques such as NMR, GC-MS, or LC-MS. Deuterium labeling also offers potential for studying and influencing drug pharmacokinetic and metabolic profiles.
- Deuterium labeled compound
- First-generation histamine H1-receptor antagonist
- Exhibits anti-cholinergic effect
- Crosses the ovine blood-brain barrier (BBB)
- Useful as a tracer in drug development
- Serves as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories L-VALINE (D8, 98%), 0.5 G, 35045-72-8
L-VALINE (D8, 98%), 0.5 G, 35045-72-8
Medchemexpress LLC Diphenhydramine-d6 hydrochloride | 1189986-72-8 | 99.3% | 5 MG
Diphenhydramine-d6 hydrochloride is the deuterium-labeled form of Diphenphenhydramine hydrochloride, a first-generation histamine H1-receptor antagonist with anti-cholinergic effects. It can cross the ovine blood-brain barrier (BBB). Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules primarily as tracers for quantitation during drug development. Deuteration, specifically, has gained attention for its potential to impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Megestrol acetate-d3 | 162462-72-8 | 387.53 | 500 UG
Megestrol acetate-d3 is a deuterium-labeled version of Megestrol acetate, a synthetic and orally active progesteronal agent. It is utilized as an appetite stimulant for wasting syndromes and decreases nuclear and cytosol androgen receptors. This compound holds potential for HIV studies and downregulates the autophagic catabolic pathway.
- Effective as an appetite stimulant for wasting syndromes such as cachexia
- Decreases nuclear and cytosol androgen receptors in human BPH tissue
- Potential for HIV study and downregulates the autophagic catabolic pathway
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs
Sigma Aldrich Fine Chemicals Biosciences D-Alanine-13C3 99 atom % 13C | 286460-72-8 | MFCD01075519 | 100MG
D-Alanine-13C3 99 atom % 13C | Mol Wt: 92.07 | 286460-72-8 | MFCD01075519 | 100MG
Medchemexpress LLC L-valine-d8 | 35045-72-8 | MFCD00144704 | 99.8% | 125.20 g·mol⁻¹ | C5H3D8NO2 | 10 MG
L-Valine-d8 is the deuterated isotopologue of the essential amino acid L-valine, labeled with eight deuterium atoms and supplied for research use as a stable isotope standard or for labeled synthesis. It is commonly used as an internal standard in mass spectrometry and for metabolic and isotopic-labeling studies.
- Deuterated with eight deuterium atoms for mass-difference applications.
- High isotopic enrichment, suitable for quantitative MS analysis.
- High chemical purity for research applications.
- Available in small solid vials and solution formats for flexible use.
Sigma Aldrich Fine Chemicals Biosciences L-Valine-d8 >=98 atom % D, >=98% (CP) | 35045-72-8 | MFCD00144704 | 1G
L-Valine-d8 >=98 atom % D, >=98% (CP) | Purity: >=98% (CP) | Mol Wt: 125.2 | 35045-72-8 | MFCD00144704 | 1G
eMolecules Medchem Express / L-Valine-d8 / 5mg / 686240710 / HY-I1124 / / 35045-72-8 / MFCD00144704 / 125.197 / C5H11NO2
Medchem Express / L-Valine-d8 / 5mg / 686240710 / HY-I1124 / / 35045-72-8 / MFCD00144704 / 125.197 / C5H11NO2
Medchemexpress LLC Α-Zearalenol-d4 | 1778734-73-8 | 500 UG
Α-Zearalenol-d4 is a deuterated labeled α-Zearalenol. Α-Zearalenol is a mycotoxin with high affinity for the estrogen receptors (ER), it is a derivative of zearalenone (ZEN), and causes reproductive disorders in animals due to its xenoestrogenic effects.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules.
- Deuteration has potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells.
- Induces an increase of cell viability on MCF-7 cells mainly after 72 hours of treatment.
- Increases MCF7 cell population in the S phase and in the G2/M phase.
- Reduces the expression of TNF-α.
- Combines with β-ZOL showing an antagonistic effect on inflammation for IL-1β and acts synergic for IL-8 at high toxin concentrations.