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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
Molecular sieves are crystalline metal aluminosilicates having a 3-dimensional interconnecting network of silica and alumina tetrahedra. Natural water of hydration is removed from this network by heating to produce uniform cavities which selectively adsorb molecules of a specific size. The 3A form is made by substituting potassium cations for the inherent sodium ions of the 4A structure reducing the effective pore size to ~3A… excluding diameter 3A… e.g. ethane. The 4 to 8-mesh type is normally used in gas-phase applications. Molecular sieves are considered a universal drying agent in polar and nonpolar media.
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SMI-4a is a selective, cell-permeable, ATP-competitive inhibitor of Pim-1 kinase supplied as a high-purity research chemical. It inhibits Pim-1 (IC50 = 24 μM; Ki = 0.6 μM) and Pim-2 (IC50 = 100 μM), is provided as a white to off-white solid in a 10 mg package, and includes recommended storage conditions for powder and solutions.
Selective ATP-competitive Pim-1 kinase inhibitor suitable for research use.
High purity suitable for biochemical and cellular assays.
Supplied as a 10 mg solid for small-scale experiments.
Includes storage recommendations for powder and dissolved samples.
Contains chemical identifiers for unambiguous compound tracking.
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Regeneration or ActivationA saturated molecular sieve can be restored to its original capacity by regeneration the principle of which involves changing the conditions surrounding the adsorbent to correspond to a very low equilibrium capacity. In general the greater the difference between the equilibrium capacities of adsorption and regeneration the more rapid and complete the regeneration.The sieve may be regenerated in one of four ways1. Thermal reactivation -The maximum regeneration temperature for Silica is 300C.2. Pressure reactivation3. Passing an appropriate fluid through the gel bed at normal temperature and pressure.4. Displacement of adsorbates by passing a high concentration of molecules in a fluid through the bed.
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U-Blot Pan Phospho-4E-BP1 (Thr37/46) Rabbit mAb is a Rabbit-derived recombinant monoclonal antibody (clone W-R32) that specifically recognizes Phospho-4E-BP1 (Thr37/46) a phosphorylation modification at Thr37/46 It shows reactivity with Human Validated applications include WB Recommended dilutions WB 1500-11000 Purified by protein a Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E leading to repress translation In contrast hyperphosphorylated form dissociates from EIF4E allowing interaction between EIF4G1/EIF4G3 and EIF4E leading to initiation of translation Besides 4E-BP1 mediates the regulation of protein translation by hormones growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways Supplied as 100 uL
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Recombinant mouse myelin-associated glycoprotein (MAG/Siglec-4a) produced in HEK293 cells and supplied as a lyophilized, C-terminal 6xHis-tagged protein for biochemical and cell-based assays. Formulated from HEPES or phosphate buffer, the product has a reported molecular weight of 70-120 kDa and demonstrated activity in SH-SY5Y inhibition assays. Store frozen and aliquot to prevent repeated freeze-thaw.
Recombinant mouse MAG/Siglec-4a for functional assays.
Expressed in HEK293 to preserve mammalian post-translational modifications.
C-terminal 6xHis tag for purification and detection.
Lyophilized from buffered saline for stability and transport.
Reported molecular weight 70-120 kDa.
Demonstrated biological activity (ED50 ~3.13 μg/mL in SH-SY5Y assays).
Store at -20°C and aliquot to minimize freeze-thaw cycles.
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SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serine/threonine- or tyrosine-kinases
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