Antibody-Binding Proteins and Conjugates
Cayman Chemical CefalothInsodIum salt 500mg
A nucleotide diphosphate for various biochemical research applications including studies of DNA synthesis substrate for nucleoside diphosphate kinases
Cayman Chemical GncIclovIrsodIum salt 50mg
A plant metabolite and an aldose reductase 2 inhibitor (IC50 17 UM) inhibits glucose-induced sorbitol accumulation in lenses isolated from a transgenic mouse model overexpressing AKR1B1 reduces methylglyoxal-induced increases in COX-2 IL-6 IL-8 CCL2 and RAGE levels in ARPE-19 retinal epithelial cells
Cayman Chemical TInptInsodIum salt 50mg
A piperazine derivative with cardioprotective activity reduces INa in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ ventricular myocytes isolated from a canine model of heart failure guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II and HEK293 cells expressing human Nav1.5 channels (IC50s 5.9-15 M) reduces IKr in canine ventricular myocytes and HEK293 cells (IC50s 11.5 and 14.4 M respectively) reduces clofilium-induced prolongation of the QTc interval and TdP in rabbits at 480 g/kg per min reduces interstitial collagen deposition as well as ANP CTGF BNP and MMP-2 mRNA levels and prevents left ventricular dilation in a mouse model of doxorubicin-induced cardiotoxicity
Cayman Chemical PPAdodIum salt 50mg
An RXR agonist (EC50s 28 25 and 20 nM for RXRa RXRB and RXRY respectively in reporter assays) selective for RXRs over RARs (RARs EC50s 10 UM for RXRa RXRB and RXRY) induces apoptosis in MJ HuT 78 and HH CTCL cells at 10 UM inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models at 100 mg/kg per day reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 9.4 UM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 2.01 UM)
Cayman Chemical D-LucIferInpotasIum salt 500mg
An inhibitor of GVIA iPLA2 inhibits GVIA iPLA2 by 99.9 at 0.091 mol fraction in a mixed micelle activity assay is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8 inhibition respectively inhibits iPLA2B activity in cytosolic extracts from INS-1 cells overexpressing iPLA2B (IC50 ~50 nM) as well as iPLA2Y activity in mouse heart membrane fractions (IC50 ~1-3 M) inhibits glucose-induced increases in PGE2 production and insulin secretion in human pancreatic islets at 10 M inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2B in a concentration-dependent manner reduces blood glucose levels in an intraperitoneal glucose tolerance test and incidence of diabetes and increases serum insulin levels in NOD mice at 20 mg/kg 3 times per week
Cayman Chemical D-LucIferInpotasIum salt 50mg
Immunogen Synthetic peptide from the N-terminal region of human NF-KB (p65) Host Rabbit Species Reactivity ( ) Human chimpanzee monkey Applications WB MW 60 kDa
Cayman Chemical EsomeprazolesodIum salt 50mg
A fluorinated analog of AEA that serves as a substrate of FAAH (Km 29 UM) used to perform n-FABS against FAAH to identify novel inhibitors
Cayman Chemical 6-SIalylactosesodIum salt 50mg
A symmetric bis-glycolamide that inhibits the eIF2a phosphorylation-mediated unfolded protein response (IC50 5 nM in a cell-reporter assay) passes through the blood-brain barrier and significantly enhances learning and memory in mice and rats
Cayman Chemical LorglumIdesodIum salt 50mg
An analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis 5.3 and 330 nM respectively) significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2
Cayman Chemical CefotetnsodIum salt 50mg
Immunogen Mixture of a peptide with 6xHis-tag at the N-terminus and another peptide with 6xHis-tag at the C-terminus Host Rabbit Species Reactivity ( ) All species Cross Reactivity ( ) Recombinant proteins containing the 6xHis-tag 10xHis-tag fused to either the amino or carboxy terminus (-) Other endogenous protein in mammalian cells or bacteria Application(s) WB FC ICC IHC and IP A probe for immunochemical detection of His tags on recombinant proteins by FC ICC IHC IP or WB
Cayman Chemical AloglIptInbenzoate salt 50mg
A modified nucleobase found in tRNAs that is known to stabilize UA pairs
Cayman Chemical DnshensusodIum salt 50mg
An M2 and M4 muscarinic acetylcholine receptor antagonist (Kis 6 03 and 10 nM respectively) selective for M2 and M4 over M1 M3 and M5 receptors (Kis 30 9 66 07 and 537 03 nM respectively) increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo following local infusion at 1 UM and in the cortex at 5 mg/kg i p reverses deficits in novel object recognition and passive avoidance in aged rats as well as scopolamine-induced deficits in young rats