Antibody-Binding Proteins and Conjugates
Cell Signaling Technology G4S Linker E7O2V Fab2 Fra
G4S Linker (E7O2V) F(ab')2 Fragment (Alexa Fluor(R) 488 Conjugate) 100 ul
Cayman Chemical Semaglutide (sodium salt), Purity: ≥98%, CAS: 2924330-56-1, 50 mg
A GLP-1R agonist (EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor); decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = <2 nmol/kg); prevents decreases in the number of dopaminergic neurons in the substantia nigra and increases in lipid peroxidation in the substantia nigra and striatum, as well as improves motor coordination in the rotarod and footprint tests in a mouse model of Parkinson’s disease induced by MPTP at 25 nmol/kg; decreases neuronal loss in the hippocampal dentate gyrus and CA1 and CA3 regions and improves motor coordination and grip strength in the beam-walking and hanging wire tests, respectively, in a rat model of stroke induced by permanent MCAO at 10 nmol/kg every other day
ALPHATHERA oYo-Link Azide Antibody Labeling Reagent - Labels 100ug
oYo-Link Azide enables site-specific labeling of azide to the heavy chain of compatible antibodies with up to two Azide labels per antibody. oYo-Link enables the click reaction to take place prior to antibody labeling which results in highly efficient click reactions.Simply mix oYo-Link Azide with your desired antibody followed by photocrosslinking for conjugation in 30-seconds hands on time, 2 hours total. Photocrosslinking can be carried out in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins
Cell Signaling Technology Protein L, PE Conjugate, Flow Cytometry, 100 μL
Protein L is a recombinant protein that interacts with the κ light chain variable domain of immunoglobulins without disrupting paratope function. Conjugated to phycoerythrin (PE), this product is specifically validated for direct flow cytometric analysis of human cells expressing κ light chain-containing immunoglobulins, including Fab fragments and single chain variable fragments (scFvs). The protein has been genetically engineered to remove cell wall, cell membrane, and albumin-binding regions to enhance specificity.
- Validated for direct flow cytometry (live)
- Recommended dilution: 1:50
- Supplied in PBS (pH 7.2) containing <0.1% sodium azide and 2 mg/mL BSA
- Species reactivity: Human, mouse, rat, and pig
- Store at 4°C, protect from light, and do not freeze
Revvity Health Sciences Inc LANCE Ultra Phospho-BTK (Tyr223) Detection Kit, 10,000 Assay Points
LANCE Ultra Phospho-BTK (Tyr223) Detection Kit, 10,000 Assay Points
Jackson Immuno Research Labs Alexa Fluor 647-ChromPure Human IgM (myeloma) whole molecule
Alexa Fluor 647-ChromPure Human IgM (myeloma) whole molecule
Jackson Immuno Research Labs Alexa Fluor 488-ChromPure Human IgG Fc fragment
Alexa Fluor 488-ChromPure Human IgG Fc fragment
MORADEC LLC Fab-αHFc-CL-DMDM, 50 μg, Human IgG Fc region specific, Cleavable linker, Alkylates DNA
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker is a specialized secondary antibody-drug conjugate designed for research applications. This product uniquely combines the Fab fragment of a polyclonal antibody with Duocarmycin DM, a cytotoxic small molecule, to facilitate targeted cell death through DNA alkylation. The cleavable linker ensures stability in extracellular environments and offers selective activation within cells for enhanced delivery of therapeutic agents. This approach creates opportunities for innovative antibody lead screening in ADC development.
- Target specificity for the human IgG Fc region
- Monovalent nature of the Fab fragment
- Stability in extracellular fluid
- Cleavable linker activated by intracellular cathepsins
- Alkylation mechanism targeting DNA minor groove
- Suitable for antibody pre-screening applications
- 50 μg quantity available
Cell Signaling Technology Caspase-3 (D3R6Y) Rabbit Monoclonal Antibody, Recombinant, Unconjugated, 100 μL
This rabbit monoclonal antibody is designed to detect endogenous levels of total caspase-3 protein, specifically recognizing both the full-length protein and the large subunit (p20) generated during proteolytic cleavage in apoptosis. The antibody is produced by immunizing animals with recombinant protein specific to the human caspase-3 p20 subunit.
- Validated for western blotting, simple western, and immunoprecipitation applications.
- Reacts with human, mouse, rat, and monkey species, with predicted reactivity in pig.
- Supplied in a stable formulation containing 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, and <0.02% sodium azide.
- Recommended storage at -20°C without aliquoting.
Phalloidin:FITC Reagent, ECM Biosciences
Phalloidin:FITC can be used for immunocytochemical and immunohistochemical labeling of actin filaments. Phalloidin:FITC binds polymeric and oligomeric actin, but does not bind monomeric actin. The conjugates can be used to label actin filaments in many species, including human, mouse, rat, chicken, and fish. The immunogen was Phalloidin conjugated to FITC via the side chain of amino acid 7. The conjugate has a molecular weight of 1250. This fluorochrome has an excitation maximum of 495 nm and emission maximum of 513 nm. Accession #. Applications = ICC, IHC; Species Reactivity = Hu, Rt, Ms, Ck, F; Size = 100 μl; Buffer = Phalloidin conjugates are supplied in 100µl PBS, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store at –20°C. Stable for 1 year. Other Names = actin