COVID Testing Kits
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
An activator of Nrf2 signaling increases the expression of Nrf2 target genes and activates HO-1 in CV-1 cells at 100 nM binds to PPARY and PPARa (Kis 344 and 232 nM respectively) and induces PPARY transactivation in SW480 cells inhibits NOS production in isolated mouse macrophages (IC50 0.014 nM) inhibits proliferation of U937 and MCF-7 cells at 300 nM reduces fatty acid synthesis in LiSa-2 human liposarcoma cells at 100 nM reduces tumor growth in a B16 murine melanoma model at 50 Ug/animal twice per day
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
A BD2 bromodomain inhibitor inhibits BD2 in BRD2 BRD3 BRD4 and BRDT (IC50s 264 98 49 and 214 nM respectively) and is selective for BD2 over BD1 (IC50s 10.96 36.31 70.55 and 50.11 UM for BRD2 BRD3 BRD4 and BDT respectively) in a TR-FRET assay inhibits IFN-Y-induced protein expression of MHC class I in K562 cells at 1 UM reduces the production of anti-KLH IgM antibodies in mice immunized with KLH at 40 mg/kg
Cayman Chemical SARSCoV2 SpIke GlycoproteIn
A BD2 bromodomain inhibitor inhibits BD2 in BRD2 BRD3 BRD4 and BRDT (IC50s 264 98 49 and 214 nM respectively) and is selective for BD2 over BD1 (IC50s 10.96 36.31 70.55 and 50.11 UM for BRD2 BRD3 BRD4 and BDT respectively) in a TR-FRET assay inhibits IFN-Y-induced protein expression of MHC class I in K562 cells at 1 UM reduces the production of anti-KLH IgM antibodies in mice immunized with KLH at 40 mg/kg