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Hardwickiic acid is a diterpenoid compound that can block tetrodotoxin-sensitive voltage-dependent sodium channels. It possesses multiple activities including insecticidal, antinociceptive, and neurotransmitter release-regulating effects. It is used in the study of neurological diseases.
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Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza. It has anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo.
Promotes the expression of eNOS and the phosphorylation of AMPKa.
Activates Nrf2/HO-1 signaling pathways.
Exhibits antioxidant and anti-apoptotic activities.
Functions as a competitive inhibitor for xanthine oxidase.
Inhibits uric acid production and superoxide radicals (SOR) production.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). It significantly reduces plasma cholesterol levels in animal models without affecting food consumption.
Potent ACAT inhibitor
Inhibits ACAT in various tissue preparations and human cell cultures
Reduces plasma cholesterol levels in cholesterol/cholic acid-fed rats
No inhibitory activity against rat PCEH or LCAT
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RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
Potent ACAT inhibitor with IC50 values ranging from 6 to 283 nM in various animal tissue preparations, and 113 to 503 nM in human cell lines (HepG2, CaCo-2, and THP-1).
No inhibitory activity was observed against rat PCEH or LCAT at concentrations up to 200 μM and 20 μM, respectively.
Administration of RP-64477 significantly reduced plasma cholesterol levels in cholesterol/cholic acid-fed rats.
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