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Tissue plasminogen activator (tPA) is a protease of the S1 family (trypsin family) and is found in a wide variety of mammalian tissues especially endothelial cells. tPA is secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. Supplied in the single chain form with a molecular weight of ~70nbspkDa. The Tissue Plasminogen Activator (tPA) gene is mapped to human chromosome 8p11.21 and encodes a protease of 69nbspkDa majorly containing serine amino acid residue. It is predominantly expressed in endothelial cells.
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A cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2); crosses the blood-brain barrier to inhibit brain cysteine protease activity; reported to have protective effects in numerous rodent models of neurotrauma and cardiac ischemia
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A 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM); shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4
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A cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2); crosses the blood-brain barrier to inhibit brain cysteine protease activity; reported to have protective effects in numerous rodent models of neurotrauma and cardiac ischemia
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome complex, which blocks activation of NFκB and the production of TNF and IL-1β
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A DNA sequence encoding the Influenza A virus ((A/California/04/2009) (H1N1)) hemagglutinin (translated amino acids of ACP41105.1), termed as HA, was expressed a polyhistidine tag at the C-terminus.
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