Cell Culture Media, Supplements, and Reagents
Apexbio Technology LLC Hexylresorcinol 136-77-6 1g
Hexylresorcinol (136-77-6) is a small-molecule inhibitor targeting mushroom tyrosinase a copper-containing enzyme catalyzing the oxidation of phenolic substrates It is designed to modulate tyrosinase activity thereby regulating melanogenesis pathways Hexylresorcinol exerts its biological activity primarily through competitive inhibition of diphenolase activity In in vitro studies Hexylresorcinol demonstrates inhibition of both monophenolase and diphenolase activities with an IC50 value of approximately 1 24 M and a Ki of about 0 443 M Based on these pharmacological properties Hexylresorcinol holds research potential in pigmentation regulation therapeutic strategies for hyperpigmentation disorders and has clinical applications in topical formulations for skin infections throat lozenges and anti-aging skincare products
MOLTOX Molecular Toxicology Inc Mitomycin C, 20 ug/vial, 5 vials/pack, Store in Refrigerator
For use in Ames test with TA102 tester strain. Dose 0.5 µg/plate. Reconstitute with organic solvents such as DMSO or sterile dH2O as applicable. Direct acting mutagens do not require the use of S9 metabolic activation to cause mutagenicity. CONTROLCHEM™ chemicals are obtained from major suppliers of research chemicals and are employed without further characterization or purification. Packaged quantities are precise within 1%. Please Note: CONTROLCHEM™ chemicals are known mutagens/carcinogens/toxins and are sold only to those experienced in the safe handling and disposal of hazardous materials. Consult your Institutional Safety Officer before ordering.
Apexbio Technology LLC Doramectin,5g CAS# 117704-25-3
Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC PRE-084 hydrochloride,10mg CAS# 75136-54-8
PRE-084 hydrochloride is a selective σ1 agonist with high affinity, rather than over PCP receptors (IC50 > 100000 nM) and several other receptor systems. It was reported that sigma (s) receptor ligands to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia, involving the s1 subtype of s receptor.In vitro: PRE-084 had an IC50 of 44 nM in the receptor assay and an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 1 0,000 nM in many other receptor systems. In general, hydroxy-substituted phenyl groups in these compounds like PRE-084 tended to have attenuated potency at a receptors, whereas methylphenyl and chlorophenyl substitutions enhanced potencies. Reduction of cycloalkyl ring size lowered potencies for a receptors and quatemized amine groups invariably decreased the compound’s potencies. [1]. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC Carbadox,100mg CAS# 6804-07-5
Carbadox is a drug that combats bacterial infection in swine, particularly swine dysentery. Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC HY-112106A 100mg Medchemexpress, Diethyl aminoethyl hexanoate citrate DA-6 citrate;2-Diethylaminoethyl hexanoate citrate CAS:220439-24-7 Purity:98%
Medchemexpress,HY-112106A 100mg Diethyl aminoethyl hexanoate citrate DA-6 citrate;2-Diethylaminoethyl hexanoate citrate CAS:220439-24-7 Formula:C18H33NO9 Diethyl aminoethyl hexanoate citrate is a compound that is widely used as a plant growth regulator. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC L-Glutamic acid monosodium salt S4721-100mg
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid found naturally in tomatoes cheese and other foods L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic kainate NMDA and AMPA) (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals
Medchemexpress LLC FGF basic/bFGF Huma 50ug
FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (154a a) consists of 154 amino acids produced by E coli with tag free
Medchemexpress LLC IL-35 Human HEK293 50ug
IL-35 protein plays a key role in immune regulation forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production IL-35 Protein Human (HEK293 His hFc-Flag) is a recombinant protein dimer complex containing human-derived IL-35 protein expressed by HEK293 with C-hFc C-Flag C-8 His labeled tag
Enzo Life Sciences Ryanodine (high purity) (5mg). CAS: 15662-33-6
Induces the release of intracellular Ca2+ . Ryanodine receptors mediate adenine nucleotide, Ca2+ and caffeine-sensitive release of Ca2+ from sarcoplasmic reticulum of cardiac and skeletal muscle and may also mediate intracellular Ca2+ release in neurons. Biphasic effect on sarcoplasmic reticulum calcium channels; Nanomolar levels open the channel and micromolar levels close it. Purity: ≥99% (HPLC). Appearance: White to off-white solid. Solubility: Soluble in methanol or DMSO (>29mg/ml), in 100% ethanol (16mg/ml); slightly soluble in water (warm). Long Term Storage: -20°C.
Apexbio Technology LLC Guanfacine hydrochloride 29110-48-3 10mg
Guanfacine hydrochloride (CAS 29110-48-3) is a selective agonist of the 2A-adrenergic receptor displaying approximately 60-fold selectivity over the 2B subtype (Kd 31 nM for 2A) Experimental studies indicate that low doses improve attention in NK1R knockout mice without affecting wild-type animals while higher doses suppress impulsivity in both genotypes In alcohol consumption models guanfacine reduces alcohol intake and attenuates alcohol deprivation effects in rats Additionally guanfacine modulates spinal nociceptive transmission through interactions with delta opioid receptors enhancing analgesic responses in nerve injury models These properties underscore its utility in studies of CNS function addiction and nociception
Medchemexpress LLC HY-80013 10mg Medchemexpress, THZ1 CAS:1604810-83-4 Purity:>98%
Medchemexpress, HY-80013 10mg THZ1 CAS:1604810-83-4 THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-101784 100mg Medchemexpress, NE 52-QQ57 CAS:1401728-56-0 Purity:>98%
Medchemexpress, HY-101784 100mg NE 52-QQ57 CAS:1401728-56-0 NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC 50 of 70 nM [1] . Anti-inflammatory activities [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.