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A USP30 inhibitor (IC50 0.12 UM) is selective for USP30 over 22 other USPs at 10 UM inhibits ubiquitinylated probe-induced active site modification of USP30 in mitochondria isolated from C2C12 myoblasts at 0.6 1.7 and 5 UM induces cell death in HSC-4 cells at 0.2 0.5 1 and 2 UM reduces tumor growth in an SCC4 squamous cell carcinoma mouse xenograft model at 1 mg/kg per day
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