Immunosuppressant Drug Testing Controls and Calibrators
Thermo Scientific™ QMS™ Tacrolimus Immunoassays and Calibrators
Achieve excellent low-end precision and sensitivity with the Thermo Scientific™ QMS™ Tacrolimus Immunoassay.
Thermo Scientific™ QMS™ Therapeutic Drug Monitoring (TDM) Calibrators
Accurately measure therapeutic drug levels in serum and plasma with Thermo Scientific™ QMS™ TDM Calibrators, offered in Levels A to F.
Thermo Scientific™ CEDIA™ Mycophenolic Acid Immunoassays, Calibrators and Controls
Complete your ISD panel with the Thermo Scientific™ CEDIA™ Mycophenolic Acid Immunoassay.
Thermo Scientific™ QMS™ Therapeutic Drug Monitoring (TDM) Controls
Ensure accurate results when testing with the newest TDM reagents with Thermo Scientific™ QMS™ TDM Controls, offered in three levels.
Thermo Scientific™ CEDIA™ Therapeutic Drug Monitoring (TDM) Calibrators
Save time while maintaining accuracy with economical Thermo Scientific™ CEDIA™ Therapeutic Drug Monitoring (TDM) Calibrators, optimized for use with CEDIA TDM Assays.
Thermo Scientific™ QMS™ Everolimus Immunoassays, Calibrators and Controls
Obtain results you can count on for immunosuppressant drug monitoring with the Thermo Scientific™ QMS™ Everolimus Immunoassay.
AdipoGen Everolimus
Chemical. CAS 159351-69-6. Formula C53H83NO14. MW 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 FKBP-12 to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin mTOR. More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to Rapamycin. Anticancer agent. Inhibition of mTOR reduces the activity of effectors downstream, which leads to a blockage in the progression of cells from G1 into S phase, and subsequently inducing cell growth arrest, apoptosis and autophagy, resulting in reduction of cell proliferation, angiogenesis and glucose uptake. Inhibits tumor proliferation in vitro and in vivo.
AdipoGen Everolimus
Chemical. CAS 159351-69-6. Formula C53H83NO14. MW 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available Rapamycin derivative that shows improved pharmacokinetics and pharmacodynamics. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 FKBP-12 to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin mTOR. More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to Rapamycin. Since mTORC2 is believed to play an important role in glucose metabolism and the immune system, selective inhibition of mTORC1 achieves many of the benefits of rapamycin without the associated glucose intolerance and immunosuppression Anticancer agent.
AdipoGen Everolimus
Chemical. CAS 159351-69-6. Formula C53H83NO14. MW 958.2. Isolated from Streptomyces hygroscopicus. Macrolide antibiotic, inhibiting bacterial protein synthesis. Orally available Rapamycin derivative that shows improved pharmacokinetics and pharmacodynamics. Potent immunosuppressant. Binds with high affinity to the FK506 binding protein-12 FKBP-12 to generate an immunosuppressive complex that inhibits the activation of the mammalian target of rapamycin mTOR. More selective for the mTORC1 protein complex, with little impact on the mTORC2 complex, compared to Rapamycin. Since mTORC2 is believed to play an important role in glucose metabolism and the immune system, selective inhibition of mTORC1 achieves many of the benefits of rapamycin without the associated glucose intolerance and immunosuppression Anticancer agent.
Cayman Chemical EverolImus-d4 1mg
A quinolone antibiotic active against Gram-positive and Gram-negative bacteria including S aureus and E coli (MICs 10 and 1 Ug/ml respectively) inhibits growth of nalidixic acid-sensitive strains of E coli in an in vitro model of bacterial cystitis at 10 and 50 mg/L active against chloroquine-sensitive and -resistant strains of P falciparum in vitro (IC50s 41 4 and 14 4 Ug/ml respectively) and against hepatic stages of P yoelii yoelii (IC50 21 6 Ug/ml)
Cayman Chemical Mycophenolc ACD mthyl Ste 50mg
An H /K -ATPase inhibitor (Ki 46 nM) inhibits histamine- or dibutyryrl-cAMP-induced acid production in isolated rabbit gastric glands (IC50s 0.28 and 0.26 UM respectively)
AdipoGen Amikacin disulfate salt
Chemical. CAS 39831-55-5. Formula C22H43N5O13 . 2H2SO4. MW 781.76. Amikacin is a broad-spectrum aminoglycoside antibiotic and a semisynthetic analog of kanamycin. It irreversibly binds to 16S rRNA and the RNA-binding S12 protein of the 30S subunit and 50S subunit of prokaryotic ribosome and inhibits protein synthesis. It works in a concentration-dependent manner, and has better action in an alkaline environment. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains, due to its resistance to inactivating enzymes. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria. Amikacin can be used to treat non-tubercular mycobacterial infections and tuberculosis when first-line drugs fail to control the infection.
Cayman Chemical MycophenolIc AcId DGlucuro 5mg
A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases
Cayman Chemical MycophenolIc AcId 50mg
An NSAID and a prodrug form of 6-methoxy naphthalene acetic acid reduces carrageenan-induced edema in rats from 5-45 mg/kg as well as UV-induced erythema in guinea pigs (ED50 11 mg/kg) reduces phenyl-p-quinone-induced writhing in mice (ED50 152 mg/kg) reduces endotoxin-induced pyresis in rabbits at 50 100 and 200 mg/kg