Custom Rearray cDNAs, shRNAs, siRNAs, and PCR Probes

R&D Systems™ Human ASGR2 (NP_001172) VersaClone cDNA

A subunit of the asialoglycoprotein receptor

R&D Systems™ VersaClone cDNA, Human LILRB4/CD85k/ILT3 (NP_001265355)

'Leukocyte Immunoglobulin-like Receptor, Subfamily B (with TM and ITIM Domains), Member 4

R&D Systems™ Mouse Hepsin (NP_032307) VersaClone cDNA

Type II membrane protein with an extracellular serine protease domain

R&D Systems™ VersaClone cDNA, Human Siglec-16 (A6NMB1)

Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of pathogens.

R&D Systems™ Human Hepsin (NP_002142) VersaClone cDNA

Serine protease hepsin catalytic chain

R&D Systems™ VersaClone cDNA, Mouse B7-1/CD80 (NP_033985)

Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA 4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA4 critical binding sites.

R&D Systems™ VersaClone cDNA, Mouse VSIG3 (NP_733548)

VSIG3/IGSF11 is an adhesion molecule that forms Ca-independent homophilic interactions

R&D Systems™ VersaClone cDNA, Mouse B7-2/CD86 (NP_062261)

B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses.

R&D Systems™ Human TfR2 (NP_003218) VersaClone cDNA

HFE3 transferrin receptor protein 2

R&D Systems™ Human ECSCR (NP_001071161) VersaClone cDNA

Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator

R&D Systems™ VersaClone cDNA, Mouse VSIG4 (NP_808457)

VSIG4 contributes significantly to innate immunity by binding and phagocytosis of complement opsonized invading pathogens

R&D Systems™ VersaClone cDNA, Mouse B7-H2 (NP_056605)

B7-H2 may play an important role in mediating local tissue responses to inflammatory conditions

R&D Systems™ VersaClone cDNA, Human CLCA2 (NP_006527)

CLCA2 plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner

R&D Systems™ VersaClone cDNA, Human CD1d (NP_001757)

CD1D localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail

R&D Systems™ Human GRID1 (NP_060021) VersaClone cDNA

Glutamate receptor delta-1 subunit; glutamate receptor, ionotropic

R&D Systems™ VersaClone cDNA, Mouse TACI/TNFRSF13B (NP_067324)

TACI may play an important role in B cell development, function, and regulation.

R&D Systems™ VersaClone cDNA, Mouse IL-12 R beta 2 (NP_032380)

Both IL-12 R subunit extracellular domains are composed of three fibronectin-like domains and two cytokine receptor homology domains. IL-12R beta 2 also has an extracellular Ig-like domain

R&D Systems™ Mouse Tie-2 (NP_038718) VersaClone cDNA

Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 2

R&D Systems™ VersaClone cDNA, Human GFR alpha-like (NP_997293)

GFRAL is a member of the glial cell line-derived neurotrophic factor (GDNF) receptor family of proteins

R&D Systems™ VersaClone cDNA, Mouse PD-L2/B7-DC (NP_067371)

The extracellular domains of mouse and human PD-L2 share approximately 72% amino acid sequence identity