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2-Deoxy-D-glucose, Tocris Bioscience™

Catalog No. 451550
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Non-metabolizable glucose analog; hexokinase substrate

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.

Chemical Identifiers

CAS 154-17-6
Molecular Formula C6H12O5
Molecular Weight (g/mol) 164.16
MDL Number MFCD00151328
InChI Key PMMURAAUARKVCB-PHUJZJCSNA-N
Synonym deoxyglucose, 2-deoxy-d-mannose, 2-deoxy-d-arabinohexose, unii-9g2mp84a8w, d-arabino-hexose, 2-deoxy, arabino-hexose, 2-deoxy, d-glucose, 2-deoxy, 3r,4s,5r-3,4,5,6-tetrahydroxyhexanal, 2 deoxyglucose, 2 deoxy d glucose
PubChem CID 17751002
IUPAC Name (4R,5S,6R)-6-(hydroxymethyl)oxane-2,4,5-triol
SMILES OC[C@H]1OC(O)C[C@@H](O)[C@@H]1O

Specifications

Quantity 50 mg
Formula Weight 164.16
Percent Purity >98%
Chemical Name or Material 2-Deoxy-D-glucose

Safety and Handling

Recommended Storage Store at +4°C
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