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3-Deazaneplanocin A hydrochloride, Tocris Bioscience™

Catalog No. 47031
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

EZH2 histone methyltransferase inhibitor

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

DZNep synthesized to Ancillary Material Grade also available.

For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Chemical Identifiers

CAS 120964-45-6
Molecular Formula C12H15ClN4O3
Molecular Weight (g/mol) 298.727
InChI Key UNSKMHKAFPRFTI-FDKLLANESA-N
Synonym 3-deazaneplanocin a hydrochloride, 3-deazaneplanocin a dznep hcl, 3-deazaneplanocin, hcl salt, 3-deazaneplanocin a dznep hydrochloride, c12h14n4o3.clh, 3-deazaneplanocin a hydrochloride hplc, --1-1r,4r,5s-3-hydroxymethyl-4,5-dihydroxy-2-cyclopenten-1-yl 4-aminoimidazo 4,5-c pyridinehydrochloridedznephydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl-3-cyclopentene-1,2-diol hydrochloride, 1s,2r,5r-5-4-amino-1h-imidazo 4,5-c pyridin-1-yl-3-hydroxymethyl cyclopent-3-ene-1,2-diol-hydrogen chloride 1/1
PubChem CID 14563109
IUPAC Name (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol;hydrochloride
SMILES C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl

Specifications

Quantity 1 mg
Formula Weight 298.73
Percent Purity >98%
Chemical Name or Material 3-Deazaneplanocin A hydrochloride

Safety and Handling

Recommended Storage Store at -20°C
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