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Tocris Bioscience™ 3-Deazaneplanocin A hydrochloride
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Catalog No. 47031
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47-031 1 mg
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Catalog No. 47-031 Supplier Tocris Bioscience™ Supplier No. 4703/1
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Description

EZH2 histone methyltransferase inhibitor

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

DZNep synthesized to Ancillary Material Grade also available.

For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Chemical Identifiers

CAS 120964-45-6
Molecular Formula C12H15ClN4O3

Specifications

Quantity 1 mg
Formula Weight 298.73
Purity >98%
Molecular Weight (g/mol) 298.727
Chemical Name or Material 3-Deazaneplanocin A hydrochloride

Safety and Handling

Recommended Storage Store at -20°C
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