Tocris™ 3PO

PFKFB3 inhibitor

Manufacturer: Tocris™ 5121/50

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Catalog No. 51-215-0

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For Research Use Only


    Inhibitors 3PO
    Purity >99
    Molecular Weight 210.23
    Quantity 50mg
    Product Type 3PO

    PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor; reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.

    • Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
    • Formula: C13H10N2O
    • CAS Number: 13309-08-5
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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