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Tocris Bioscience™ 5-Iodotubercidin
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Catalog No. 17451
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17-451 1 mg
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Catalog No. 17-451 Supplier Tocris Bioscience™ Supplier No. 1745/1
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Description

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Chemical Identifiers

CAS 24386-93-4
Molecular Formula C11H13IN4O4

Specifications

Quantity 1 mg
Formula Weight 392.15
Purity 97%
Molecular Weight (g/mol) 392.15
Chemical Name or Material 5-Iodotubercidin

Safety and Handling

Recommended Storage Store at -20°C
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