Invitrogen™ ABCA1 Polyclonal Antibody

Catalog No.	Quantity
PA132129	100 μL

Catalog No. PA132129 Supplier Invitrogen™ Supplier No. PA132129

Description

Rabbit Polyclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Specifications

• Antigen: ABCA1
• Applications: ChIP Assay, ELISA, Flow Cytometry, Gel Shift, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: Abca1
• Gene Accession No.: O95477, P41233
• Gene Alias: ABC 1; ABC 1 antibody; ABC Transporter 1; Abc1; ABC-1; ABC1 antibody; Abca1; ATP binding cassette subfamily A member 1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, subfamily A (ABC1), member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette, sub-family A member 1; CERP; CERP antibody; Cholesterol efflux regulatory protein; HDLDT1; membrane-bound; phospholipid-transporting ATPase ABCA1; phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; TGD
• Gene Symbols: Abca1
• Host Species: Rabbit
• Immunogen: Partial peptide sequence (within residues 1100-1300) of human ABCA1.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100152112, 100761226, 11303, 19, 313210, 373945, 481651
• Target Species: Human, Mouse, Rat, Canine, Hamster, Pig, Chicken, Mustelid
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG